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Titolo:
HORMONAL-REGULATION OF CARDIAC CYSTIC-FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CHLORIDE CHANNELS
Autore:
HORIE M; OBAYASHI K; XIE LH; JAMES AF; SASAYAMA S;
Indirizzi:
KYOTO UNIV,FAC MED,DEPT INTERNAL MED 3,DIV CARDIAC ELECTROPHYSIOL KYOTO 60601 JAPAN
Titolo Testata:
Japanese Heart Journal
fascicolo: 5, volume: 37, anno: 1996,
pagine: 661 - 671
SICI:
0021-4868(1996)37:5<661:HOCCTC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIG VENTRICULAR MYOCYTES; CFTR CL CHANNELS; ANGIOTENSIN-CONVERTING ENZYME; PROTEIN-KINASE; MYOCARDIAL-INFARCTION; AUTONOMIC REGULATION; CHOLINERGIC MODULATION; ATP HYDROLYSIS; ION CHANNELS; HEART;
Keywords:
CARDIAC CL- CHANNEL; CFTR; BETA-ADRENERGIC AGONISTS; ALPHA-ADRENERGIC AGONISTS; ENDOTHELIN-I; ANGIOTENSIN-II; ARRHYTHMOGENIC ACTIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
72
Recensione:
Indirizzi per estratti:
Citazione:
M. Horie et al., "HORMONAL-REGULATION OF CARDIAC CYSTIC-FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CHLORIDE CHANNELS", Japanese Heart Journal, 37(5), 1996, pp. 661-671

Abstract

The chloride conductance that arises from the stimulation of beta-adrenoceptors has been shown to be carried by a cardiac isoform of cysticfibrosis transmembrane conductance regulator (CFTR) Cl- channels. This brief review will focus first upon the cellular signal transduction system for the activation of this type of Cl- channels and then its regulation by catecholamines, muscarinic agonists, endothelin-1 and angiotensin-II. Both in physiological and pathological conditions, the complex interaction of these agonists modulates the Cl- conductance, which is potentially arrhythmogenic by shortening the action potential duration and inducing the depolarization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:40:27