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Titolo:
HSF4, A NEW MEMBER OF THE HUMAN HEAT-SHOCK FACTOR FAMILY WHICH LACKS PROPERTIES OF A TRANSCRIPTIONAL ACTIVATOR
Autore:
NAKAI A; TANABE M; KAWAZOE Y; INAZAWA J; MORIMOTO RI; NAGATA K;
Indirizzi:
KYOTO UNIV,CHEST DIS RES INST,DEPT CELL BIOL,SAKYO KU KYOTO 606 JAPAN KYOTO PREFECTURAL UNIV,DEPT HYG KYOTO 606 JAPAN NORTHWESTERN UNIV,DEPT BIOCHEM MOL BIOL & CELL BIOL EVANSTON IL 60208
Titolo Testata:
Molecular and cellular biology
fascicolo: 1, volume: 17, anno: 1997,
pagine: 469 - 481
SICI:
0270-7306(1997)17:1<469:HANMOT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-BINDING ABILITY; COILED-COIL; NORMAL TEMPERATURES; GENE-TRANSCRIPTION; MOLECULAR-CLONING; FACTOR CONTAINS; HSP70 GENE; FACTOR-II; CELLS; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
A. Nakai et al., "HSF4, A NEW MEMBER OF THE HUMAN HEAT-SHOCK FACTOR FAMILY WHICH LACKS PROPERTIES OF A TRANSCRIPTIONAL ACTIVATOR", Molecular and cellular biology, 17(1), 1997, pp. 469-481

Abstract

Heat shock transcription factors (HSFs) mediate the inducible transcriptional response of genes that encode heat shock proteins and molecular chaperones. In vertebrates, three related HSF genes (HSF1 to -3) and the respective gene products (HSFs) have been characterized. We report the cloning and characterization of human HSF4 (hHSF4), a novel member of the hHSF family that shares properties with other members of the HSF family yet appears to be functionally distinct. hHSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. hHSF4 is preferentially expressed in the human heart, brain, skeletal muscle, and pancreas. Transient transfection of hHSF4 in HeLa cells, which do not express hHSF4, results in a constitutively active DNA binding trimer which, unlike other members ofthe HSF family, lacks the properties of a transcriptional activator. Constitutive overexpression of hHSF4 in HeLa cells results in reduced expression of the endogenous hsp70, hsp90, and hsp27 genes. hHSF4 represents a novel hHSF that exhibits tissue-specific expression and functions to repress the expression of genes encoding heat shock proteins and molecular chaperones.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 07:45:27