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Titolo:
DIFFERENTIAL REGULATION OF NEUROGENESIS BY THE 2 XENOPUS GATA-1 GENES
Autore:
XU RH; KIM J; TAIRA M; LIN JJ; ZHANG CH; SREDNI D; EVANS T; KUNG HF;
Indirizzi:
NCI,FREDERICK CANC RES & DEV CTR,DIV BASIC SCI,LAB BIOCHEM PHYSIOL FREDERICK MD 21702 NCI,FREDERICK CANC RES & DEV CTR,DIV BASIC SCI,LAB BIOCHEM PHYSIOL FREDERICK MD 21702 NICHHD,NIH,GENET MOL LAB BETHESDA MD 20892 ALBERT EINSTEIN COLL MED,DEPT DEV & MOL BIOL BRONX NY 10461 BAR ILAN UNIV,DEPT INTERDISCIPLINARY IL-52900 RAMAT GAN ISRAEL
Titolo Testata:
Molecular and cellular biology
fascicolo: 1, volume: 17, anno: 1997,
pagine: 436 - 443
SICI:
0270-7306(1997)17:1<436:DRONBT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE MORPHOGENETIC PROTEIN-4; TRANSCRIPTION FACTOR GATA-2; NEURAL INDUCTION; VENTRALIZING FACTOR; MESODERM INDUCTION; SPEMANN ORGANIZER; BINDING PROTEINS; EARLY RESPONSE; MESSENGER-RNA; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
R.H. Xu et al., "DIFFERENTIAL REGULATION OF NEUROGENESIS BY THE 2 XENOPUS GATA-1 GENES", Molecular and cellular biology, 17(1), 1997, pp. 436-443

Abstract

Previously, we have shown that the ventralizing factor bone morphogenetic protein 4 (BMP-4) can inhibit Xenopus neurogenesis. The erythroidtranscription factor GATA-1 functions downstream of the BMP-4 signaling pathway and mediates BMP-4-induced erythropoiesis. We hare found that similar to BMP-4, GATA-1b inhibits neuralization of Xenopus animal cap (AC) cells. The neural inhibition is not seen with GATA-1a, although both GATA-1a and GATA-1b RNAs are translated at the same efficiencyand induce globin expression equally in AC cells. GATA-1b RNA injection into AC cells neither induces expression of Xbra (a general mesoderm marker) nor affects expression of XK81 (epidermal keratin) or BMP-4 and Xvent-1 (two ventral markers). These data suggest that GATA-1b retains the epidermal fate of the AC. Intact GATA-1b protein is required for both inhibition of neurogenesis and induction of globin expression. Our findings indicate that GATA-1b can function in ectoderm to specifically regulate neural inducing mechanisms, apparently related to theexpression of chordin, a neuralizing gene. Furthermore, tadpole stageembryos injected with GATA-1b are devoid of all dorsoanterior structures including neural tissue. This report provides evidence that the two transcription factors, derived from a recent genome duplication, share a common biological activity (stimulation of erythropoiesis) white also exhibiting a distinct function (inhibition of neurogenesis).

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Documento generato il 18/01/20 alle ore 21:32:59