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Titolo:
A STRUCTURED RETROVIRAL RNA ELEMENT THAT MEDIATES NUCLEOCYTOPLASMIC EXPORT OF INTRON-CONTAINING RNA
Autore:
ERNST RK; BRAY M; REKOSH D; HAMMARSKJOLD ML;
Indirizzi:
UNIV VIRGINIA,MYLES H THALER CTR AIDS & HUMAN RETROVIRUS RES CHARLOTTESVILLE VA 22908 UNIV VIRGINIA,MYLES H THALER CTR AIDS & HUMAN RETROVIRUS RES CHARLOTTESVILLE VA 22908 UNIV VIRGINIA,DEPT MICROBIOL CHARLOTTESVILLE VA 22908
Titolo Testata:
Molecular and cellular biology
fascicolo: 1, volume: 17, anno: 1997,
pagine: 135 - 144
SICI:
0270-7306(1997)17:1<135:ASRRET>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; ENV MESSENGER-RNA; LATE REPLACEMENT VECTOR; REV-RESPONSIVE ELEMENT; PFIZER MONKEY VIRUS; CAP-BINDING-PROTEIN; NUCLEAR EXPORT; HIV-1 REV; ACTIVATION DOMAIN; SPLICE SITES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
R.K. Ernst et al., "A STRUCTURED RETROVIRAL RNA ELEMENT THAT MEDIATES NUCLEOCYTOPLASMIC EXPORT OF INTRON-CONTAINING RNA", Molecular and cellular biology, 17(1), 1997, pp. 135-144

Abstract

A common feature of gene expression in all retroviruses is that unspliced, intron-containing RNA is exported to the cytoplasm despite the fact that cellular RNAs which contain introns are usually restricted tothe nucleus. In complex retroviruses, the export of intron-containingRNA is mediated by specific viral regulatory proteins (e.g., human immunodeficiency virus type 1 [HIV-1] Rev) that bind to elements in the viral RNA. However, simpler retroviruses do not encode such regulatoryproteins. Here,ve show that the genome of the simpler retrovirus Mason-Pfizer monkey virus (MPMV) contains an element that serves as an autonomous nuclear export signal for intron-containing RNA. This element is essential for MPMV replication; however, its function can be complemented by HIV-I Rev and the Rev-responsive element. The element can also facilitate the export of cellular intron-containing RNA. These results suggest that the MPMV element mimics cellular RNA transport signals and mediates RNA export through interaction with endogenous cellularfactors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 06:39:38