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Titolo:
PROTEASOME ALPHA-TYPE SUBUNIT C9 IS A PRIMARY TARGET OF AUTOANTIBODIES IN SERA OF PATIENTS WITH MYOSITIS AND SYSTEMIC LUPUS-ERYTHEMATOSUS
Autore:
FEIST E; DORNER T; KUCKELKORN U; SCHMIDTKE G; MICHEEL B; HIEPE F; BURMESTER GR; KLOETZEL PM;
Indirizzi:
HUMBOLDT UNIV BERLIN,CHARITE UNIV HOSP,INST BIOCHEM,MONBIJOUSTR 2A D-10117 BERLIN GERMANY HUMBOLDT UNIV BERLIN,CHARITE UNIV HOSP,INST BIOCHEM D-10117 BERLIN GERMANY HUMBOLDT UNIV BERLIN,CHARITE UNIV HOSP,DEPT MED 3 D-10117 BERLIN GERMANY MAX DELBRUCK CTR MOL MED D-13125 BERLIN GERMANY
Titolo Testata:
The Journal of experimental medicine
fascicolo: 4, volume: 184, anno: 1996,
pagine: 1313 - 1318
SICI:
0022-1007(1996)184:4<1313:PASCIA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTICATALYTIC PROTEINASE; THERMOPLASMA-ACIDOPHILUM; RHEUMATIC DISEASES; REVISED CRITERIA; 20S PROTEASOME; DERMATOMYOSITIS; POLYMYOSITIS; CLASSIFICATION; ASSOCIATION; ANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
E. Feist et al., "PROTEASOME ALPHA-TYPE SUBUNIT C9 IS A PRIMARY TARGET OF AUTOANTIBODIES IN SERA OF PATIENTS WITH MYOSITIS AND SYSTEMIC LUPUS-ERYTHEMATOSUS", The Journal of experimental medicine, 184(4), 1996, pp. 1313-1318

Abstract

Autoantibodies occur in low frequencies among patients with myositis characterizing only distinct subsets of this disease. Most of these known antibodies are directed to enzymatically active complexes. The 20Sproteasome represents an essential cytoplasmatic protein complex for intracellular nonlysosomal protein degradation, and is involved in major histocompatibility complex class I restricted antigen processing Inthis study we investigated whether the 20S proteasome complex is an antibody target in myositis and in other autoimmune diseases. 34 sera of poly/dermatomyositis patients were assayed for antiproteasomal antibodies using enzyme-linked immunosorbent assay, immunoblot, and two-dimensional non-equilibrium pH gradient electrophoresis (NEPHGE). Sera was from patients with systemic lupus erythematosus (SLE), mixed connective tissue disease, and rheumatoid arthritis; healthy volunteers served as controls. In 62% (21/34) of the cases sera from patients with myositis and in 58% (30/52) of the cases sera from patients with SLE reacted with the 20S proteasome. These frequencies exceeded those of sera from patients with mixed connective tissue disease, rheumatoid arthritis, and healthy controls. The alpha-type subunit C9 of the 20S proteasome was determined to be the predominant target of the autoimmune serain myositis and SLE. Lacking other frequent autoantibodies in myositis, the antiproteasome antibodies are the most common humoral immune response so far detected in this disease entity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:52:29