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Titolo:
EFFICIENCY OF AN EXTERNAL SUPPORT TO REDUCE LIPID INFILTRATION INTO VENOUS GRAFTS - IN-VITRO EVALUATION
Autore:
DENG XY; MAROIS Y; GUIDOIN R; MERHI Y; STROMAN P; KING MW; DOUVILLE Y;
Indirizzi:
UNIV LAVAL,DEPT SURG,ROOM 1701 SERV BLDG ST FOY PQ G1K 7P4 CANADA UNIV LAVAL,DEPT SURG ST FOY PQ G1K 7P4 CANADA QUEBEC BIOMAT INST ST FOY PQ CANADA MONTREAL HEART INST,LAB THROMBOSIS & ATHERSCLEROSIS MONTREAL PQ H1T 1C8 CANADA
Titolo Testata:
Artificial organs
fascicolo: 11, volume: 20, anno: 1996,
pagine: 1208 - 1214
SICI:
0160-564X(1996)20:11<1208:EOAEST>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY LIPOPROTEIN; AUTOGENOUS VEIN GRAFTS; I-125 ALBUMIN; BYPASS GRAFTS; ATHEROSCLEROSIS; RABBIT; WALL; LDL; CIRCULATION; FILTRATION;
Keywords:
FILTRATION RATE; LIPID INFILTRATION; VENOUS GRAFT; ARTERIAL PROSTHESES; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
X.Y. Deng et al., "EFFICIENCY OF AN EXTERNAL SUPPORT TO REDUCE LIPID INFILTRATION INTO VENOUS GRAFTS - IN-VITRO EVALUATION", Artificial organs, 20(11), 1996, pp. 1208-1214

Abstract

Excessive distension of venous grafts due to arterial pressure enhances the convective water transport (filtration flow) through the vesselwall, and thus might affect the infiltration of macromolecules such as lipoproteins, In this paired experimental study, filtration velocities were measured at 100 mm Hg for canine jugular veins with or withoutexternal supports of expanded polytetrafluoroethylene (ePTFE) arterial prostheses. In addition, to assess the effect of filtration velocityon lipid infiltration or uptake, canine jugular veins were wrapped over half of their lengths with ePTFE arterial prostheses and perfused with dog serum containing H-3-cholesterol at a pressure of 100 mm Hg, At 100 mm Hg, the average filtration velocity of the wrapped jugular veins was 7.9 +/- 1.3 x 10(-6) cm/s whereas the average filtration velocity of the unwrapped veins was 27.3 +/- 2.7 x 10(-6) cm/s (p < 0.005). Moreover, the unwrapped veins had a significantly higher uptake rate of labeled cholesterol than the wrapped veins (10.9 +/- 7.3 x 10(-4) cm/h and 5.0 +/- 1.6 x 10(-4) cm/h, respectively, p < 0.005). In conclusion, under arterial pressure, Veins experience excessive distention, which leads to significant increases in both filtration flow and cholesterol uptake. An external wrap or support of ePTFE material protects veins from excessive distension and thus may prevent atherosclerosis in venous grafts by reducing cholesterol uptake.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:36:45