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Titolo:
EFFECTS OF BENZODIAZEPINE RECEPTOR INVERSE AGONISTS AND NICOTINE ON BEHAVIORAL VIGILANCE IN SENESCENT RATS
Autore:
TURCHI J; HOLLEY LA; SARTER M;
Indirizzi:
OHIO STATE UNIV,DEPT PSYCHOL,27 TOWNSHEND HALL COLUMBUS OH 43210 OHIO STATE UNIV,DEPT PSYCHOL COLUMBUS OH 43210 OHIO STATE UNIV,NEUROSCI PROGRAM COLUMBUS OH 43210
Titolo Testata:
The journals of gerontology. Series A, Biological sciences and medical sciences
fascicolo: 3, volume: 51, anno: 1996,
pagine: 225 - 231
SICI:
1079-5006(1996)51:3<225:EOBRIA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICAL ACETYLCHOLINE-RELEASE; BASAL FOREBRAIN LESIONS; SIGNAL-DETECTION THEORY; BIDIRECTIONAL MODULATION; CHOLINERGIC SYSTEM; INDUCED IMPAIRMENT; LIGANDS; ANTAGONIST; AGE; ATTENTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
J. Turchi et al., "EFFECTS OF BENZODIAZEPINE RECEPTOR INVERSE AGONISTS AND NICOTINE ON BEHAVIORAL VIGILANCE IN SENESCENT RATS", The journals of gerontology. Series A, Biological sciences and medical sciences, 51(3), 1996, pp. 225-231

Abstract

Previous experiments demonstrated that, compared with 6-month-old rats, the performance of 20-month-old rats in a behavioral vigilance taskwas characterized by an impairment in their ability to detect brief visual signals, whereas their ability to discriminate between longer signals and nonsignal events was unaffected. The benzodiazepine receptor(BZR) agonist chlordiazepoxide potently and selectively interacted with the effects of age on the relative number of hits. However, negative modulators of GABAergic transmission (ZK 93426 beta-CCtB, 33965) failed to attenuate the effects of age on behavioral vigilance. The present experiment tested the hypothesis that the performance of senescent animals (28 months) is further impaired and thus would allow the demonstration of beneficial effects of BZR inverse agonists or nicotine. However, administration of ZK 93426 (0.39, 1.56, 6.25 mg/kg). RU 33965 (0.1, 0.5 mg/kg), or nicotine (0.09, 0.287, 0.689 mg/kg) did not beneficially affect the performance of senescent animals: rather, detrimental effects were found. Considering the beneficial behavioral effects ofthese compounds in, animals with experimentally induced impairments in cholinergic function, the present findings point to limitations of normal aging as a variable in animal experiments on BZR inverse agonistor nicotine-induced attenuation of cognitive impairments that result from cholinergic hypofunction.

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Documento generato il 07/07/20 alle ore 12:12:26