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Titolo:
ILOPROST EFFECTS ON PHAGOCYTES IN PATIENTS SUFFERING FROM ISCHEMIC DISEASES - IN-VIVO EVIDENCE FOR DOWN-REGULATION OF ALPHA-M-BETA(2) INTEGRIN
Autore:
MAZZONE A; MAZZUCCHELLI I; FOSSATI G; GRITTI D; GIROLA S; CANALE C; CUSA C; RICEVUTI G;
Indirizzi:
UNIV PAVIA,S MATTEO HOSP,IRCCS,DEPT INTERNAL MED,P GOLGI 2 I-27100 PAVIA ITALY UNIV PAVIA,DEPT INTERNAL MED I-27100 PAVIA ITALY UNIV PAVIA,THERAPEUT SECT MED THERAPY I-27100 PAVIA ITALY
Titolo Testata:
European journal of clinical investigation
fascicolo: 10, volume: 26, anno: 1996,
pagine: 860 - 866
SICI:
0014-2972(1996)26:10<860:IEOPIP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTACYCLIN ANALOG ILOPROST; EXPERIMENTAL INFARCT SIZE; ENDOTHELIAL-CELLS; ADHESION MOLECULES; LEUKOCYTE ADHESION; INTRAVENOUS ILOPROST; RAYNAUDS-PHENOMENON; NEUTROPHIL; ACTIVATION; ATHEROSCLEROSIS;
Keywords:
ILOPROST; INTEGRINS; PHAGOCYTES; PROGRESSIVE SYSTEMIC SCLEROSIS; PERIPHERAL ARTERY OCCLUSIVE DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
A. Mazzone et al., "ILOPROST EFFECTS ON PHAGOCYTES IN PATIENTS SUFFERING FROM ISCHEMIC DISEASES - IN-VIVO EVIDENCE FOR DOWN-REGULATION OF ALPHA-M-BETA(2) INTEGRIN", European journal of clinical investigation, 26(10), 1996, pp. 860-866

Abstract

This study has been designed to demonstrate the in vivo effects of iloprost therapy on expression of adhesion molecules on phagocytes. Sixty patients suffering from peripheral arterial occlusive disease (PAOD)and/or from skin ulcers due to secondary progressive systemic sclerosis (PSS) were enrolled in a double-blind controlled parallel study. Thirty patients (group I) underwent iloprost infusion and 30 patients (group II) were treated with aspirin. Clinical assessment and measurement of phagocyte activation ii? who, using quantitative flow cytometry, were performed on entry and after 6 h on the first day of therapy. After 3 months of therapy, complete healing of all cutaneous lesions was observed in 84% of the patients treated with iloprost compared with the control patients (P < 0.001). Neutrophils and mono cytes of PAOD andPSS patients showed a significant decrease in the expression of the alpha M beta(2) integrin adhesion receptor after 6 h of iloprost infusion. Neutrophils and monocytes released a lower amount of anion superoxide (O-2-) after 6 h of iloprost treatment. These data confirm other clinical observations but demonstrate that in vivo this drug modifies the expression of the alpha M beta(2) integrin of phagocytes that has akey role in leukocyte-endothelium interactions in cases of inflammation and thrombosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:08:20