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Titolo:
ANALYSIS OF THE ROLE OF CALMODULIN-BINDING AND SEQUESTRATION IN NEUROMODULIN (GA1-43) FUNCTION
Autore:
GAMBY C; WAAGE MC; ALLEN RG; BAIZER L;
Indirizzi:
GOOD SAMARITAN HOSP,RS DOW NEUROL SCI INST,1120 NW 20TH AVE PORTLAND OR 97209 GOOD SAMARITAN HOSP,RS DOW NEUROL SCI INST PORTLAND OR 97209 OREGON HLTH SCI UNIV,CTR RES OCCUPAT & ENVIRONM TOXICOL PORTLAND OR 97201 OREGON HLTH SCI UNIV,DEPT CELL BIOL & ANAT PORTLAND OR 97201
Titolo Testata:
The Journal of biological chemistry
fascicolo: 43, volume: 271, anno: 1996,
pagine: 26698 - 26705
SICI:
0021-9258(1996)271:43<26698:AOTROC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-ASSOCIATED PROTEIN; KINASE-C SUBSTRATE; BRAIN POLYPHOSPHOINOSITIDE METABOLISM; MEMBRANE TARGETING DOMAIN; LONG-TERM POTENTIATION; B-50 GAP-43; NEURITE OUTGROWTH; NERVOUS-SYSTEM; RAT-BRAIN; ADULT-RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
85
Recensione:
Indirizzi per estratti:
Citazione:
C. Gamby et al., "ANALYSIS OF THE ROLE OF CALMODULIN-BINDING AND SEQUESTRATION IN NEUROMODULIN (GA1-43) FUNCTION", The Journal of biological chemistry, 271(43), 1996, pp. 26698-26705

Abstract

We demonstrated previously that forced expression of the neuronal phosphoprotein neuromodulin (also known as GAP-43, F1, B-50, and p57) in mouse anterior pituitary AtT-20 cells enhances depolarization mediated. secretion and alters cellular morphology. Here we analyze the role of calmodulin binding by neuromodulin in these responses, In cells expressing mild-type neuromodulin, a complex with calmodulin that is sensitive to intracellular calcium and phosphorylation is localized to the plasma membrane, Transfection of several mutant forms of neuromodulin shows that the effects of this protein on secretion are dependent on both calmodulin binding and association with the plasma membrane, In contrast, the morphological changes depend only oh membrane association. Thus, the multitude of effects of neuromodulin noted in previous studies may result from divergent properties of this protein.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:30:23