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Titolo:
ONTOGENY OF HORMONAL AND EXCRETORY FUNCTION OF THE MESONEPHROS AND METANEPHROS IN THE OVINE FETUS
Autore:
WINTOUR EM; ALCORN D; BUTKUS A; CONGIU M; EARNEST L; POMPOLO S; POTOCNIK SJ;
Indirizzi:
UNIV MELBOURNE,HOWARD FLOREY INST EXPT PHYSIOL & MED PARKVILLE VIC 3052 AUSTRALIA UNIV MELBOURNE,DEPT ANAT & CELL BIOL PARKVILLE VIC 3052 AUSTRALIA
Titolo Testata:
Kidney international
fascicolo: 5, volume: 50, anno: 1996,
pagine: 1624 - 1633
SICI:
0085-2538(1996)50:5<1624:OOHAEF>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; HUMAN-KIDNEY; DEVELOPMENTAL EXPRESSION; RECEPTOR SUBTYPES; GENE-EXPRESSION; RENAL-FUNCTION; MESSENGER-RNA; MOUSE KIDNEY; FETAL; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
E.M. Wintour et al., "ONTOGENY OF HORMONAL AND EXCRETORY FUNCTION OF THE MESONEPHROS AND METANEPHROS IN THE OVINE FETUS", Kidney international, 50(5), 1996, pp. 1624-1633

Abstract

Using reverse-transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry we investigated the ontogeny of renin, angiotensinogen and angiotensin converting enzyme (ACE) in the mesonephros at 27 and 41 days of gestation, and the metanephros at 41 and 64 days of gestation in ovine fetuses (term is 145 to 150 days). The volume and composition of fetal urine, stored as allantoic fluid were measured in 12 fetuses at 27 days, and 13 fetuses at 41 days. Renin. angiotensinogen and ACE were identified in both meso- and metanephroi at 41 days but not in the mesonephros at 27 to 30 days. Allantoic fluid volumes were 21+/- 3 and 45 +/- 5 ml at 27 to 30 days and 41 days, respectively. This fluid aas significantly different in composition to that of amnioticfluid or maternal plasma. The results suggest that the mesonephros can substantially modify its glomerular filtrate by 27 days of gestation, and can produce local angiotensin II by 41 days.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 16:34:43