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Titolo:
CHANGES OF BLOOD-PRESSURE RESPONSIVENESS IN RATS EXPOSED IN-UTERO ANDPERINATALLY TO A HIGH-SALT ENVIRONMENT
Autore:
ARGUELLES J; LOPEZSELA P; BRIME JI; COSTALES M; VIJANDE M;
Indirizzi:
UNIV OVIEDO,DPTO BIOL FUNC OVIEDO SPAIN
Titolo Testata:
Regulatory peptides
fascicolo: 1-2, volume: 66, anno: 1996,
pagine: 113 - 115
SICI:
0167-0115(1996)66:1-2<113:COBRIR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NACL EXPOSURE; APPETITE;
Keywords:
BLOOD PRESSURE; HEART RATE; ANGIOTENSIN II; SALT INTAKE; PREGNANCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
J. Arguelles et al., "CHANGES OF BLOOD-PRESSURE RESPONSIVENESS IN RATS EXPOSED IN-UTERO ANDPERINATALLY TO A HIGH-SALT ENVIRONMENT", Regulatory peptides, 66(1-2), 1996, pp. 113-115

Abstract

We tested the hypothesis that the presser responses to angiotensin IIcould be influenced by an early salt exposure. Twenty-five adult female rats were pseudorandomly divided in two groups. Twelve animals underwent a partial ligature of their abdominal aorta (PAL). Once polydipsia and sodium appetite developed, these rats were mated. The other group (13 rats) was sham-operated (Sham) and mated. Throughout pregnancy and lactation, water and 2.7% NaCl solution intakes differed between the two groups of mother rats. PAL offspring (PAL-O; n = 14), and Sham-operated offspring (Sh-O; n = 10), were maintained on a solid diet containing 1% NaCl, tap water and a 2.7% NaCl solution. At 90 days of age, presser responsiveness to intravenous angiotensin II (50, 100 and 200 ng) was assessed in anesthetized rats. The presser responses to 50 and 200 ng angiotensin II were significantly greater in PAL-O rats thanin Sh-O rats. These results support the hypothesis of a modulation ofcardiovascular responsiveness or its underlying mechanisms by an early high salt environment.

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Documento generato il 21/09/20 alle ore 12:11:58