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Titolo:
EFFECTS OF INTRACEREBROVENTRICULAR INJECTIONS OF LOSARTAN OR PD123319ON ARTERIAL-PRESSURE AND HEART-RATE OF SODIUM REPLETE AND SODIUM DEPLETE RATS
Autore:
DELUCA LA; BARBOSA SP; SUGAWARA AM; MENANI JV;
Indirizzi:
PAULISTA STATE UNIV,UNESP,SCH ODONTOL,DEPT PHYSIOL SCI BR-14801906 ARARAQUARA SP BRAZIL
Titolo Testata:
Regulatory peptides
fascicolo: 1-2, volume: 66, anno: 1996,
pagine: 31 - 35
SICI:
0167-0115(1996)66:1-2<31:EOIIOL>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-II; VENTROLATERAL MEDULLA; RECEPTOR ANTAGONIST; BLOOD-PRESSURE; RESPONSES;
Keywords:
ANGIOTENSIN II; SODIUM DEPLETION; ANGIOTENSIN RECEPTOR SUBTYPE; AT(1) RECEPTOR; AT(2) RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
L.A. Deluca et al., "EFFECTS OF INTRACEREBROVENTRICULAR INJECTIONS OF LOSARTAN OR PD123319ON ARTERIAL-PRESSURE AND HEART-RATE OF SODIUM REPLETE AND SODIUM DEPLETE RATS", Regulatory peptides, 66(1-2), 1996, pp. 31-35

Abstract

Angiotensin II (Ang II) non-peptide antagonists were injected i.c.v. (6.25-200 nmol, n = 5-8 rats/group). In sodium replete rats, losartan (AT(1) receptor antagonist) induced an increase in mean arterial pressure (MAP) and in heart rate (HR) by 3rd ventricular (3rdV) injection, and an weaker presser response and bradycardia by 4th ventricular (4thV) injection, PD123319 (AT(2) receptor antagonist) induced an increasein MAP acid in HR by 3rdV injection, and an increase in MAP and no alteration in HR by 4thV injection. In sodium deplete (furosemide plus removal of ambient sodium for 24 h) rats, losartan induced an increase in MAP and no alteration in HR by 3rdV injection, and no alteration inMAP and bradycardia by 4thV injection. PD123319 induced an increase in MAP and in HR by 3rdV injection, and an increase in MAP and bradycardia by 4thV injection. Thus, there were no fall in MAP by central injections of Ang II antagonists. Intravenous injection of losartan, but not of PD123319, induced a fall in MAP in both sodium replete and sodium deplete animals. Therefore, losartan and PD123319 can have similar effects on MAP and HR when injected intracerebroventricularly, althoughsome differences are also present. The bradycardia is consistent withan withdrawal of Ang II inhibitory action on baroreflex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:12:28