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Titolo:
DOPAMINE TRANSPORTER BINDING IN RAT STRIATUM AND NUCLEUS-ACCUMBENS ISUNALTERED FOLLOWING CHRONIC CHANGES IN DOPAMINE LEVELS
Autore:
MOODY CA; GRANNEMAN JG; BANNON MJ;
Indirizzi:
WAYNE STATE UNIV,SCH MED,DEPT PSYCHIAT & BEHAV NEUROSCI,CELLULAR & CLIN NEUROBIOL PROGRAM DETROIT MI 48201 WAYNE STATE UNIV,SCH MED,DEPT PSYCHIAT & BEHAV NEUROSCI,CELLULAR & CLIN NEUROBIOL PROGRAM DETROIT MI 48201
Titolo Testata:
Neuroscience letters
fascicolo: 1, volume: 217, anno: 1996,
pagine: 55 - 57
SICI:
0304-3940(1996)217:1<55:DTBIRS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
UPTAKE SITES; RECEPTORS; 6-HYDROXYDOPAMINE; COCAINE;
Keywords:
DOPAMINE; DOPAMINE TRANSPORTER; [H-3] WIN-35,428; [H-3] MAZINDOL; ALPHA-METHYL-P-TYROSINE; L-DOPA; STRIATUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Moody et al., "DOPAMINE TRANSPORTER BINDING IN RAT STRIATUM AND NUCLEUS-ACCUMBENS ISUNALTERED FOLLOWING CHRONIC CHANGES IN DOPAMINE LEVELS", Neuroscience letters, 217(1), 1996, pp. 55-57

Abstract

The effects of chronic treatment with the tyrosine hydroxylase inhibitor a-methyltyrosine or the dopamine precursor L-3,4-dihydrox yphenylalanine on radioligand binding to the dopamine transporter in homogenates of rat striatum and nucleus accumbens were assessed. Chronic alpha-methyltyrosine administration decreased dopamine levels in both the striatum and nucleus accumbens without a resulting change in [H-3]mazindol binding to the dopamine transporter in either brain region. In a second experiment, chronic administration of a-methyltyrosine or L-3,4-dihydroxyphenylalanine produced significant decreases and increases, respectively, in striatal dopamine levels without altering the binding of [H-3]WIN-35,428, a chemically distinct dopamine transporter radioligand. These data suggest that even dramatic fluctuations in brain dopamine levels do not modulate the abundance of the dopamine transporter.

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Documento generato il 21/01/21 alle ore 04:18:11