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Titolo:
DAY 3 SERUM INHIBIN-B IS PREDICTIVE OF ASSISTED REPRODUCTIVE TECHNOLOGIES OUTCOME
Autore:
SEIFER DB; LAMBERTMESSERLIAN G; HOGAN JW; GARDINER AC; BLAZAR AS; BERK CA;
Indirizzi:
OHIO STATE UNIV,MED CTR,DIV REPROD ENDOCRINOL,5TH FLOOR,MEANS HALL,ROOM 529,1654 UPHAM DR COLUMBUS OH 43210 BROWN UNIV,SCH MED,CTR STAT SCI PROVIDENCE RI 02912
Titolo Testata:
Fertility and sterility
fascicolo: 1, volume: 67, anno: 1997,
pagine: 110 - 114
SICI:
0015-0282(1997)67:1<110:D3SIIP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICLE-STIMULATING-HORMONE; IN-VITRO FERTILIZATION; INVITRO FERTILIZATION; MENSTRUAL-CYCLE; DIMERIC INHIBIN; ESTRADIOL; BASAL; WOMEN; AGE;
Keywords:
INHIBIN-B; OVARIAN RESERVE; ART;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
D.B. Seifer et al., "DAY 3 SERUM INHIBIN-B IS PREDICTIVE OF ASSISTED REPRODUCTIVE TECHNOLOGIES OUTCOME", Fertility and sterility, 67(1), 1997, pp. 110-114

Abstract

Objective: To determine if women with day 3 serum inhibin-B concentrations < 45 pg/mL (conversion factor to SI unit. 1.00) demonstrate a poorer response to ovulation induction and assisted reproductive technologies outcome relative to women with inhibin-B values greater than or equal to 45 pg/mL. Design: Analysis of inhibin-B, FSH, and E(2) concentrations in day 3 serum samples. Setting: Academic clinical practice. Patient(s): One hundred fifty-six women who underwent 178 assisted reproductive technology (ART) cycles with luteal phase GnRH agonist suppression plus hMG and urofollitropin stimulation. Main Outcome Measure(s): Serum E(2) on day of hCG, number of oocytes retrieved per patient, fertilization rate, cleavage rate, clinical pregnancy rate (PR) per initiated cycle, cancellation rate por initiated cycle, and spontaneous abortion rate. Result(s): Women with day 3 serum inhibin-B < 45 pg/mL demonstrated 70% of the E(2) response, had 66.6% of the number of oocytes retrieved per patient, with 28% of the clinical PR per initiated cycle, and three times the cancellation rate per initiated cycle than women with day 3 inhibin-B greater than or equal to 45 pg/mL. After controlling for age, day 3 serum FSH, day 3 serum E(2), patient cycle number, and method of ART, day 3 serum inhibin-B greater than or equal to45 pg/mL was noted to be prognostic of the number of oocytes retrieved and clinical PR. The adjusted odds ratio of clinical pregnancy for those with day 3 serum inhibin-B greater than or equal to 45 pg/mL versus those with inhibin-B < 45 pg/mL was 6.8 (95% confidence interval 1.8 to 25.6). Conclusion(s): Women with low day 3 serum inhibin-B concentrations demonstrate a poorer response to ovulation induction and are less likely to conceive a clinical pregnancy through ART relative to women with high day 3 inhibin-B.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 18:37:30