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Titolo:
PREVENTION OF SEMINIFEROUS TUBULAR ATROPHY IN A NATURALLY CRYPT ORCHID RAT MODEL BY EARLY SURGICAL INTERVENTION
Autore:
LUGG JA; PENSON DF; SADEGHI F; PETRIE B; FREEDMAN AL; GONZALEZCADAVID NF; HIKIM AS; RAJFER J;
Indirizzi:
UNIV CALIF LOS ANGELES,HARBOR MED CTR,DIV UROL,DEPT SURG,SCH MED TORRANCE CA 90509 UNIV CALIF LOS ANGELES,HARBOR MED CTR,DIV UROL,DEPT SURG,SCH MED TORRANCE CA 90509
Titolo Testata:
Journal of andrology
fascicolo: 6, volume: 17, anno: 1996,
pagine: 726 - 732
SICI:
0196-3635(1996)17:6<726:POSTAI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TESTICULAR DESCENT; CRYPTORCHIDISM;
Keywords:
CRYPTORCHIDISM; ORCHIOPEXY; TESTIS DESCENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Lugg et al., "PREVENTION OF SEMINIFEROUS TUBULAR ATROPHY IN A NATURALLY CRYPT ORCHID RAT MODEL BY EARLY SURGICAL INTERVENTION", Journal of andrology, 17(6), 1996, pp. 726-732

Abstract

In an attempt to determine whether the seminiferous tubular atrophy of the cryptorchid testis is preventable by early surgical correction of the cryptorchid state, aberrantly developed gubernacula destined to result in a cryptorchid testis in the Long-Evans cryptorchid (LE/ORL) rat were surgically reimplanted to the bottom of the scrotum on day 10to 12 of age, Testis descent was monitored and the changes in testicular histology and in the volumes of the seminiferous tubules and Leydig cells were examined at day 60, As expected, normal testis descent occurred on or about day 25. Compared to untreated undescended testes atday 60, relative seminiferous tubular volumes (volume, % +/- SEM) were significantly increased by early surgical reimplantation of the gubernacula (89 +/- 1 vs, 66 +/- 3; P < 0.01), Absolute seminiferous tubular volumes (mu l +/- SEM) were also significantly increased by early surgical intervention when compared to undescended nontreated testes (893 +/- 27 vs, 170 +/- 12; P < 0.01), The testes of the surgically corrected cryptorchid animals were similar in ail respects to those found in the descended testes of the sham-operated controls. Relative Leydigcell volume (% +/- SEM) was increased in the untreated cryptorchid testes compared to the surgically corrected testes (5.2 +/- 0.6 vs. 1.2 /- 1.0; P < 0.05). Relative Leydig cell volumes in the surgically corrected testes were not significantly different from those found in thesham-operated descended controls. A modest but significant (P < 0.05)increase in absolute Leydig cell volume was also noted in the cryptorchid testes when compared both to normal controls or surgically corrected cryptorchid testes. From these observations, we conclude that early gubernaculopexy reverses the histologic changes normally seen in thecryptorchid rat testis to a relatively normal histologic architecture. These data provide experimental evidence to support the Value of orchiopexy in the treatment of cryptorchidism.

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Documento generato il 04/12/20 alle ore 12:55:49