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Titolo:
FORMYLCOLCHICINE BOUND TO LACTOSAMINATED SERUM-ALBUMIN IS A MORE ACTIVE ANTIFIBROTIC AGENT THAN FREE COLCHICINE
Autore:
PALMERINI CA; SACCARDI C; FLORIDI A; ARIENTI G;
Indirizzi:
UNIV PERUGIA,DEPT MOL & CELLULAR BIOL,VIA DEL GIOCHETTO I-06100 PERUGIA ITALY UNIV PERUGIA,DEPT BIOL CHEM I-06100 PERUGIA ITALY
Titolo Testata:
Clinica chimica acta
fascicolo: 2, volume: 254, anno: 1996,
pagine: 149 - 157
SICI:
0009-8981(1996)254:2<149:FBTLSI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC-FIBROSIS; LIVER-DISEASE; CIRRHOSIS; RATS;
Keywords:
CARBON TETRACHLORIDE; COLCHICINE; FORMYLATED COLCHICINE; HYDROXYPROLINE; LIVER FIBROSIS; LACTOSAMINATED SERUM ALBUMIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Palmerini et al., "FORMYLCOLCHICINE BOUND TO LACTOSAMINATED SERUM-ALBUMIN IS A MORE ACTIVE ANTIFIBROTIC AGENT THAN FREE COLCHICINE", Clinica chimica acta, 254(2), 1996, pp. 149-157

Abstract

Liver fibrosis was induced by chronically (7 weeks) administering CCl4 to rats. Animals were divided into four groups: (a) controls, (b) treated with CCl4 alone, (c) treated with CCl4 and colchicine and (d) treated with CCl4 and formyl-colchicine bound to lactosaminated serum albumin (FC-LASA). Liver dysfunction was monitored by biochemical tests (alkaline phosphatase [ALP], gamma-glutamyltransferase [gamma GT], aspartate and alanine transaminases [AST and ALT], albumin and total bilirubin). Fibrosis was evaluated by determining hydroxyproline and by microscopic examination. The exposure to CCl4 produced major alterationsof liver structure and collagen deposition. These effects were partially counteracted by colchicine and to a greater extent by FC-LASA. Morphological findings paralleled biochemical data. The information reported here indicates that colchicine has an antifibrotic activity on theliver of intoxicated rats and that FC-LASA is more active than colchicine itself as an antifibrotic agent.

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Documento generato il 13/08/20 alle ore 02:34:31