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Titolo:
GROWTH-HORMONE INDUCES SOMATOSTATIN AND INSULIN-LIKE GROWTH-FACTOR-I GENE-EXPRESSION IN THE CEREBRAL HEMISPHERES OF AGING RATS
Autore:
LOPEZFERNANDEZ J; SANCHEZFRANCO F; VELASCO B; TOLON RM; PAZOS F; CACICEDO L;
Indirizzi:
HOSP RAMON Y CAJAL,DEPT ENDOCRINOL,CARRETERA COLMENAR KM 9-1 MADRID 28034 SPAIN HOSP RAMON Y CAJAL,DEPT ENDOCRINOL MADRID 28034 SPAIN CTR NACL INVEST CLIN,INST CARLOS 3 MADRID 28034 SPAIN
Titolo Testata:
Endocrinology
fascicolo: 10, volume: 137, anno: 1996,
pagine: 4384 - 4391
SICI:
0013-7227(1996)137:10<4384:GISAIG>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER RIBONUCLEIC-ACIDS; CENTRAL-NERVOUS-SYSTEM; SOMATOMEDIN-C; TRANSGENIC MICE; IGF-I; HYPOPHYSECTOMIZED RATS; CONTAINING NEURONS; BRAIN; CELLS; CULTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
J. Lopezfernandez et al., "GROWTH-HORMONE INDUCES SOMATOSTATIN AND INSULIN-LIKE GROWTH-FACTOR-I GENE-EXPRESSION IN THE CEREBRAL HEMISPHERES OF AGING RATS", Endocrinology, 137(10), 1996, pp. 4384-4391

Abstract

The neuropeptide somatostatin (SS) plays a role as a modulator of cognitive functions and as a potential tropic factor in the central nervous system. A reduction in SS levels has been demonstrated in the agingbrain and in dementia. In addition, insulin-like growth factor I (IGF-I) acts as a paracrine factor in multiple GH actions and is also found in the cerebral hemispheres, where it exerts neurotropic effects. Weused aging rats as an in vivo model of GH deficiency to study the possible participation of exogenous GH in the modulation of the cerebral hemispheric SS and IGF-I. Two sets of experiments were carried out. Inthe first set, the age-related patterns of GH, IGF-I, and SS in the serum, pituitary, and cerebral hemispheres were established. In the second experimental set, 90-day-old (adult) and 2-yr-old (aging) male rats received recombinant human GH (200 mu g/ sc . day) or vehicle for 7 consecutive days. The serum levels of rat GH and IGF-I as well as pituitary GH messenger RNA decreased in 2-yr-old rats compared with those in adult rats. After GH treatment, pituitary GH messenger RNA levels decreased markedly in the 90-day-old and 2-yr-old rats. Serum immunoreactive GH decreased in the adult animals, whereas it remained unaffected in the aging ones, whereas serum IGF-I levels were not altered by GHtreatment in either group. Immunoreactive levels and messenger RNA ofboth SS and IGF-I were low in the cerebral hemispheres of aging rats,but were restored to the levels found in adult rats after GH treatment. As treatment did not induce changes in the serum IGF-I levels, these results provide evidence of a stimulatory action of peripherally administered GH on the regulation of SS and IGF-I genes in the aging rat in the central nervous system. These data also show a new target action for GH and could provide a molecular basis for the improvement of some symptoms of GH deficiency that occurs after recombinant human GH treatment.

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Documento generato il 30/11/20 alle ore 07:19:08