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Titolo:
EFFECTS OF ADRENOMEDULLIN AND CALCITONIN-GENE-RELATED PEPTIDE ON AIRWAY AND PULMONARY VASCULAR SMOOTH-MUSCLE IN GUINEA-PIGS
Autore:
PINTO A; SEKIZAWA K; YAMAYA M; OHRUI T; JIA YX; SASAKI H;
Indirizzi:
TOHOKU UNIV,SCH MED,DEPT GERIATR MED,AOBA KU,SEIRYO MACHI 1-1 SENDAI MIYAGI 980 JAPAN TOHOKU UNIV,SCH MED,DEPT GERIATR MED,AOBA KU SENDAI MIYAGI 980 JAPAN
Titolo Testata:
British Journal of Pharmacology
fascicolo: 7, volume: 119, anno: 1996,
pagine: 1477 - 1483
SICI:
0007-1188(1996)119:7<1477:EOAACP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL PEPTIDE; SUBSTANCE-P; NITRIC-OXIDE; CGRP 8-37; INDUCED VASODILATION; ANTAGONIST CGRP8-37; HYPOTENSIVE PEPTIDE; PERFUSED KIDNEY; RELAXING FACTOR; ENDOTHELIUM;
Keywords:
AIRWAY SMOOTH MUSCLE; PULMONARY ARTERY; ENDOTHELIUM; ADRENOMEDULLIN; CALCITONIN GENE-RELATED PEPTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
A. Pinto et al., "EFFECTS OF ADRENOMEDULLIN AND CALCITONIN-GENE-RELATED PEPTIDE ON AIRWAY AND PULMONARY VASCULAR SMOOTH-MUSCLE IN GUINEA-PIGS", British Journal of Pharmacology, 119(7), 1996, pp. 1477-1483

Abstract

1 The airway and pulmonary vascular effects of adrenomedullin were studied in the guinea-pig isolated trachea, main bronchi and pulmonary artery in vitro and compared to the effects of calcitonin gene-related peptide (CGRP). 2 In tracheal rings, CGRP (1 nM to 1 mu M) potentiatedthe cholinergic contractions induced by electrical field stimulation (EFS) at 5 Hz in a concentration-dependent manner. At a concentration of 1 mu M, CGRP slightly decreased the responses to log EFs frequency,producing 50% of the maximum contraction from a control value of 0.77/-0.10 Hz to 0.54+/-0.05 Hz without a significant effect on the concentration-response curves to acetylcholine (ACh). In contrast, adrenomedullin (1 nM to 1 mu M) not alter either EFS-induced cholinergic or ACh-induced contractions. 3 In bronchial strips, CGRP (1 nM to 1 mu M) slightly reduced both the non-adrenergic non-cholinergic (NANC) contraction induced by EFS at 10 Hz and the substance P (1 mu M)-induced contraction in a concentration-dependent manner, whereas adrenomedullin (1nm to 1 mu M) was without effect. 4 Neither CGRP (1 mu M) nor adrenomedullin (1 mu M) altered NANC relaxation induced by EFs at 5 Hz in tracheal rings precontracted with histamine (10 mu M).5 Adrenomedullin (1nM to 1 mu M) and CGRP (1 nM to 1 mu M) induced a concentration-dependent relaxation of the histamine (10 mu M)- and prostaglandin F-2 alpha (10 mu M)-precontracted pulmonary arterial rings with intact endothelium with a similar potency. 6 Neither removal of the endothelium nor N-G-nitro-L-arginine methyl ester (100 mu M) altered the vasorelaxant effects of adrenomedullin (1 nM to 1 mu M) and CGRP (1 nM to 1 mu M). 7 The putative CGRP receptor antagonist CGRP(8-37) (1 mu M to 10 mu M)concentration-dependently attenuated the CGRP (3 nM to 30 nM)-inducedvasorelaxant actions, whereas it had no effect on the relaxation of vessel rings induced by adrenomedullin (3 nM to 30 nM). 8 These resultssuggest that adrenomedullin is a potent vasodilator of the pulmonary artery without any bronchomotor effect in the guinea-pig lung, and that the vasorelaxant actions of adrenomedullin are not mediated via the activation of CGRP(1) receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:06:59