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Titolo:
MODEL OF STREPTOCOCCUS-PNEUMONIAE MENINGITIS IN ADULT-RATS
Autore:
STRAKE JG; MITTEN MJ; EWING PJ; ALDER JD;
Indirizzi:
ABBOTT LABS,DEPT COMPARAT MED ABBOTT PK IL 60064 ABBOTT LABS,DEPT ANTI INFECT ABBOTT PK IL 00000
Titolo Testata:
Laboratory animal science
fascicolo: 5, volume: 46, anno: 1996,
pagine: 524 - 529
SICI:
0023-6764(1996)46:5<524:MOSMIA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESISTANT PNEUMOCOCCAL MENINGITIS; EXPERIMENTAL PENICILLIN-RESISTANT; BACTERIAL-MENINGITIS; DEXAMETHASONE TREATMENT; UNITED-STATES; HEARING-LOSS; PATHOPHYSIOLOGY; CEPHALOSPORINS; SURVEILLANCE; CHILDREN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
J.G. Strake et al., "MODEL OF STREPTOCOCCUS-PNEUMONIAE MENINGITIS IN ADULT-RATS", Laboratory animal science, 46(5), 1996, pp. 524-529

Abstract

The purpose of this study was to develop a model of bacterial meningitis in young adult rats for assessing the efficacy of antimicrobial agents, Sixty 200- to 300-g male Sprague Dawley CD rats were inoculated intracisternally with 5.78 log(10) CFU of a clinical isolate of Streptococcus pneumoniae in 5% hog gastric mucin. Inoculated rats mere assigned to six groups containing 10 animals each, Group-1 rats served as controls and did not receive antibiotics, Rats of groups 2 to 4 received (subcutaneously every 12 h) cefotaxime (25, 6.25, and 1.56 mg/kg of body weight respectively). Rats of groups 5 and 6 received ampicillin (50 and 12.5 mg/kg respectively) and gentamicin (2.0 and 0.5 mg/kg respectively), Five additional Sprague Dawley CD rats were inoculated with only gastric hog mucin and were assigned to group 7. At postinoculation day 4 all animals were euthanized. Cerebral spinal fluid was collected for culturing, Brains were harvested for histologic examination and culturing, Untreated, infected control (group-1) animals were culture-positive for S. pneumoniae in the brain and cerebral spinal fluid. Of the antibiotic regimens evaluated, only cefotaxime (25 mg/kg) eradicated bacteria from the cerebral spinal fluid and brain, Cefotaxime at25 or 6.25 mg/kg significantly (P less than or equal to 0.05) decreased the bacterial burden of S. pneumoniae, whereas cefotaxime at 1.56 mg/kg and ampicillin/gentamicin combinations did not, There was histopathological evidence of subacute meningitis in infected rats, No meningitis was observed in rats receiving 25 mg of cefotaxime/kg. This modeldemonstrates the ability to induce bacterial meningitis with S. pneumoniae in adult rats and the ability to clear infection in 90 to 100% of the animals by administration of cefotaxime at dosages of 6.25 and 25 mg/kg given subcutaneously every 12 h.

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Documento generato il 06/04/20 alle ore 08:23:11