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Titolo:
THE EFFECT OF PROSTACYCLIN AND NITRIC-OXIDE ON DEFORMABILITY OF RED-BLOOD-CELLS IN SEPTIC SHOCK IN RATS
Autore:
KORBUT R; GRYGLEWSKI RJ;
Indirizzi:
JAGIELLONIAN UNIV,COLL MED,DEPT PHARMACOL,GRZEGORZECKA 16 PL-31531 KRAKOW POLAND
Titolo Testata:
Journal of Physiology and Pharmacology
fascicolo: 4, volume: 47, anno: 1996,
pagine: 591 - 599
SICI:
0867-5910(1996)47:4<591:TEOPAN>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMORPHONUCLEAR LEUKOCYTES; ERYTHROCYTE DEFORMABILITY; SYNTHASE; HYPOTENSION; INHIBITION; INVITRO; SYSTEM;
Keywords:
RED BLOOD CELL DEFORMABILITY; SEPTIC SHOCK; PROSTACYCLIN (PGI(2)); ILOPROST; NITRIC OXIDE (NO); NITRIC OXIDE-SYNTHASE INHIBITION; LIPOPOLYSACCHARIDE (LPS);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
R. Korbut e R.J. Gryglewski, "THE EFFECT OF PROSTACYCLIN AND NITRIC-OXIDE ON DEFORMABILITY OF RED-BLOOD-CELLS IN SEPTIC SHOCK IN RATS", Journal of Physiology and Pharmacology, 47(4), 1996, pp. 591-599

Abstract

Six hours after administration of E. Coli endotoxin (LPS) into rats (10 mg kg(-1), i.p.) a significant (P<0.001) decline in the red blood cell deformability index (RBC D-i) was observed. The control Di value of untreated animals it was 300+/-39 RBC x 10(6)/min (mean+/-S.D.; n = 12) while in LPS treated animals was 140+/-50 RBC x 10(6)/min; n = 12. Pretreatment of the animals with the stable analogue of prostacyclin,iloprost (30 mu g/kg, i.p.) or with the inhibitor of thromboxane A(2)-synthase, camonagrel (10 mg/kg, i.p.), but not with nitric oxide donor, such as GEA 5285 (10 mg/kg, i.p.), significantly increased deformability of red blood cells in the group of non-septicaemic animals, and antagonized the LPS-induced decline in red blood cell deformability ofsepticaemic rats. Administration of N-G-nitro-L-aginine (L-NNA, 30 mg/kg, i.p.), as that of aspirin (50 mg/kg, i.p.), did not affect red brood cell deformability in non-septicaemic rats, however, in contrast with aspirin, it significantly improved deformability of red blood cells in LPS-treated animals. It is concluded that prostacyclin, camonagrel and L-NNA can act as protective agents against LPS-lnduced loss of red blood cell deformability. The mechanisms of this protection are complex and, possibly, related to the specific effects of these agents onbiochemical function of leukocytes present in RBC suspension. While the effect of exogenous prostacyclin (iloprost) may be explained on thebasis of its direct cytoprotective potency on leukocytes, the effect of camonagrel is indirect and can be attributed both to the release ofendogenous prostacyclin and to the inhibition of thromboxane A(2)-synthase. The protection induced by NO-synthase inhibitor seems to dependupon inhibition of an increase of the generation of nitric oxide which follows administration of LPS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 16:55:00