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Titolo:
SYNTHESIS AND ANTITUMOR-ACTIVITY OF NEW DERIVATIVES OF FLAVONE-8-ACETIC ACID (FAA) .1. 6-METHYL DERIVATIVES
Autore:
AITKEN RA; BIBBY MC; DOUBLE JA; PHILLIPS RM; SHARMA SK;
Indirizzi:
UNIV ST ANDREWS,SCH CHEM ST ANDREWS KY16 9ST FIFE SCOTLAND UNIV ST ANDREWS,SCH CHEM ST ANDREWS KY16 9ST FIFE SCOTLAND UNIV BRADFORD,CLIN ONCOL UNIT BRADFORD BD7 1DP W YORKSHIRE ENGLAND
Titolo Testata:
Archiv der pharmazie
fascicolo: 11, volume: 329, anno: 1996,
pagine: 489 - 497
SICI:
0365-6233(1996)329:11<489:SAAOND>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLAVONE ACETIC-ACID; KILLER CELL-ACTIVITY; 9-OXO-9H-XANTHENE-4-ACETIC ACID; BLOOD-FLOW; AGENTS; COLON; INVIVO; NSC-347512; ANALOGS; MICE;
Keywords:
FLAVONE ACETIC ACID; SYNTHESIS; ANTITUMOR ACTIVITY; STRUCTURE-ACTIVITY RELATIONSHIPS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Aitken et al., "SYNTHESIS AND ANTITUMOR-ACTIVITY OF NEW DERIVATIVES OF FLAVONE-8-ACETIC ACID (FAA) .1. 6-METHYL DERIVATIVES", Archiv der pharmazie, 329(11), 1996, pp. 489-497

Abstract

A range of 17 derivatives of flavone-8-acetic acid (FAA) with a B-methyl substituent have been prepared and their anti-tumour activity evaluated in vitro against a panel of human and murine tumour cell lines and in vivo against MAC 15A. While many of the compounds show activity comparable to FAA in vitro, this essentially disappears in vivo, possibly due to degradation before the compounds can reach the tumour site.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:48:37