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Titolo:
P53 AND RB1 PROTEIN EXPRESSION - ARE THEY PROGNOSTICALLY USEFUL IN COLORECTAL-CANCER
Autore:
POLLER DN; BAXTER KJ; SHEPHERD NA;
Indirizzi:
QUEEN ALEXANDRA HOSP,DEPT PATHOL PORTSMOUTH PO6 3LY HANTS ENGLAND GLOUCESTERSHIRE ROYAL HOSP,DEPT HISTOPATHOL GLOUCESTER GL1 3NN ENGLAND GLOUCESTERSHIRE ROYAL HOSP,GLOUCESTER GASTROENTEROL GRP GLOUCESTER GL1 3NN ENGLAND
Titolo Testata:
British Journal of Cancer
fascicolo: 1, volume: 75, anno: 1997,
pagine: 87 - 93
SICI:
0007-0920(1997)75:1<87:PARPE->2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-PROLIFERATION; TERM PROGNOSIS; GENE-PRODUCT; MUTATIONS; OVEREXPRESSION; CARCINOMA; SURVIVAL; MUTANT; ADENOCARCINOMA; ASSOCIATION;
Keywords:
COLORECTAL CANCER; P53; RB1; PROGNOSIS; CELL CYCLE-ASSOCIATED PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
D.N. Poller et al., "P53 AND RB1 PROTEIN EXPRESSION - ARE THEY PROGNOSTICALLY USEFUL IN COLORECTAL-CANCER", British Journal of Cancer, 75(1), 1997, pp. 87-93

Abstract

The expression of the p53 and Rb1 proteins was examined in an unselected consecutive series of 250 primary operable colorectal carcinomas with a mean follow-up of 4.3 years (range 43-77 months). The overall cancer-specific mortality was 34.8%, with 87 cancer deaths and 35 deathsas the result of other causes. Expression of p53 protein was identified in 152 of 250 (60.8%) cases, with expression of Rbl protein in 207 of 250 (82.8%) cases. There was no association of p53 or Rb protein expression with patient age, sex, tumour site, tumour size, tumour type,tumour grade, peritumoral fibrosis, tumour lymphocytic infiltrate, nature of the tumour margin, extramural vascular invasion, number of lymph nodes or high apical lymph node involved or local peritoneal infiltration by tumour, Dukes' stage or Jass group. There was no difference in overall survival or recurrence-free survival for those cases that showed p53 expression or Rb1 protein expression compared with those cases showing absence of p53 or Rbl protein expression, although patientswith tumours showing aberrant (reduced) Rb1 protein expression demonstrated shorter recurrence-free survival and overall survival. The effect of 'aberrant' Rb1 protein expression and shorter recurrence-free and overall survival did not, however, achieve independent statistical significance. The results from this study would suggest that expressionof p53 and Rbl proteins does not appear be useful in determining the prognosis of operable colorectal cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 23:29:55