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Titolo:
VITAMIN-K STATUS AND BONE MASS IN WOMEN WITH AND WITHOUT AORTIC ATHEROSCLEROSIS - A POPULATION-BASED STUDY
Autore:
JIE KSG; BOTS ML; VERMEER C; WITTEMAN JCM; GROBBEE DE;
Indirizzi:
UNIV LIMBURG,DEPT BIOCHEM,POB 616 NL-6200 MD MAASTRICHT NETHERLANDS UNIV LIMBURG,DEPT BIOCHEM NL-6200 MD MAASTRICHT NETHERLANDS UNIV LIMBURG,CARDIOVASC RES INST MAASTRICHT NL-6200 MD MAASTRICHT NETHERLANDS ERASMUS UNIV ROTTERDAM,SCH MED,DEPT EPIDEMIOL & BIOSTAT ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,SCH MED,CARDIOVASC RES INST ROTTERDAM ROTTERDAM NETHERLANDS
Titolo Testata:
Calcified tissue international
fascicolo: 5, volume: 59, anno: 1996,
pagine: 352 - 356
SICI:
0171-967X(1996)59:5<352:VSABMI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM UNDERCARBOXYLATED OSTEOCALCIN; GAMMA-CARBOXYGLUTAMIC ACID; URINARY CALCIUM EXCRETION; ELDERLY WOMEN; DEVELOPMENTAL APPEARANCE; CARDIOVASCULAR-DISEASE; ORAL ANTICOAGULANTS; GLA PROTEIN; CALCIFICATION; RISK;
Keywords:
VITAMIN-K; GAMMACARBOXYGLUTAMATE; OSTEOCALCIN; CALCIFICATION; ATHEROSCLEROSIS; BONE MASS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
K.S.G. Jie et al., "VITAMIN-K STATUS AND BONE MASS IN WOMEN WITH AND WITHOUT AORTIC ATHEROSCLEROSIS - A POPULATION-BASED STUDY", Calcified tissue international, 59(5), 1996, pp. 352-356

Abstract

Gammacarboxyglutamate (Gla) is an uncommon amino acid formed by vitamin K action. Increasing evidence indicates that Gla-proteins are involved in the regulation of calcification processes in both bone tissue and atherosclerotic vessel wall. In a population-based study we have previously shown that in a group of 113 postmenopausal women the presence of abdominal aortic calcifications is associated with a reduced vitamin K status. In the present study we investigated whether this reduced vitamin K status was also associated with differences in bone mass or circulating calciotropic hormone levels. Serum immunoreactive ostcocalcin with low affinity for hydroxyapatite (irOC(free)) was used as a marker for vitamin K status. After correction for age it was found that women with atherosclerotic calcifications had a 7% lower bone mass as measured by metacarpal radiogrammetry (mean difference: 3.2 mm(2), 95% CI: -0.2-6.5, P = 0.06). No differences between both groups of women were observed for serum intact parathyroid hormone (PTH) and serum 25-hydroxyvitamin D levels. In the atherosclerotic women (n = 34), markers for vitamin K status were inversely associated with bone mass (r =-0.47, P = 0.013), whereas no such association was found in the atherosclerotic women in this study may be at higher risk for osteoporotic fractures as evidenced by their lower bone mass and higher serum irOC(free) levels. The finding that in atherosclerotic women vitamin K status is associated with bone mass supports our hypothesis that vitamin Kstatus affects the mineralization processes in both bone and in atherosclerotic plaques.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:13:05