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Titolo:
SERUM AND TISSUE MEASUREMENTS OF CA72-4 IN PATIENTS WITH ENDOMETRIAL CARCINOMA
Autore:
HAREYAMA H; SAKURAGI N; MAKINODA S; FUJIMOTO S;
Indirizzi:
HOKKAIDO UNIV,SCH MED,DEPT OBSTET & GYNECOL,KITA KU,NORTH 15,WEST 7 SAPPORO HOKKAIDO 060 JAPAN HOKKAIDO UNIV,SCH MED,DEPT OBSTET & GYNECOL,KITA KU SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
Journal of Clinical Pathology
fascicolo: 12, volume: 49, anno: 1996,
pagine: 967 - 970
SICI:
0021-9746(1996)49:12<967:SATMOC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODY; CA-125; RADIOIMMUNOASSAY; ANTIGEN; TAG-72; CANCER;
Keywords:
ENDOMETRIAL CARCINOMA; CA72-4; TUMOR MARKER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
H. Hareyama et al., "SERUM AND TISSUE MEASUREMENTS OF CA72-4 IN PATIENTS WITH ENDOMETRIAL CARCINOMA", Journal of Clinical Pathology, 49(12), 1996, pp. 967-970

Abstract

Aims - To evaluate the clinical usefulness of CA72-4 as a serum tumour marker for endometrial carcinoma and to investigate its immunohistochemical localisation in endometrial carcinoma cells. Methods-Serum concentrations of CA72-4 were determined in 72 patients with endometrial carcinoma. Immunohistochemical localisation of CA72-4 was investigatedusing the streptavidin-biotin method, using monoclonal antibodies B72.3 and CC49. Results-Serum CA72-4 was increased above the cut off value in 31.9% of the patients with endometrial carcinoma. Serum CA72-4 positivity was correlated with depth of myometrial invasion, adnexal metastasis, lymphovascular space involvement, and pelvic and para-aortic lymph node metastasis. Multivariate analysis showed a significant correlation between serum CA72-4 positivity and adnexal metastasis. The serum concentrations of CA125 and CA19-9, which could be tumour markers for endometrial carcinoma, were measured at the same time. In seven of72 patients increased concentrations of serum CA72-4 were found whilethose for CA125 and CA19-9 were within the normal ranges; in four of the seven patients the disease had spread beyond the uterus. Immunohistochemical positivity for CA72-4 antigen was 76.9% and occurred in thetumour cell membrane and cytoplasm. There was no significant difference in immunohistochemical positivity between patients with increased CA72-4 and those with normal CA72-4 values. Conclusions-The measurementof serum concentrations of CA 72-4 could be useful for predicting andmonitoring the progress of disease-for example, extra-corporeal spread.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 10:39:22