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Titolo:
PRESENCE OF PREDICTIVE MARKERS OF TYPE-I PREDIABETES MELLITUS IN FIRST DEGREE RELATIVES OF TYPE-I DIABETES-MELLITUS
Autore:
RODRIGUEZVILLAR C; CONGET I; ESMATJES E; LEVY I; CALVET J; FIGUEROLA D; BERGUA M; GUTIERREZ A; MIRALLES J; MILLAN M; PEIG M; GOMIS R;
Indirizzi:
HOSP CLIN BARCELONA,SERV ENDOCRINOL & NUTR,VILLARROEL 170 BARCELONA SPAIN HOSP CLIN BARCELONA,SERV ENDOCRINOL BARCELONA SPAIN FDN SARDA FARRIOL,SERV ENDOCRINOL BARCELONA SPAIN FDN CARRASCO FORMIGUERA,SERV ENDOCRINOL BARCELONA SPAIN CTR ASISTENCIA PRIMARIA,SERV ENDOCRINOL LLEIDA SPAIN CTR HOSP,SERV ENDOCRINOL MANRESA BARCELONA SPAIN UNIV HOSP,SERV ENDOCRINOL SALAMANCA SPAIN MUTUA TERRASSA,SERV ENDOCRINOL BARCELONA SPAIN RESIDENCIA ICS,SERV ENDOCRINOL MENORCA SPAIN
Titolo Testata:
Medicina Clinica
fascicolo: 10, volume: 107, anno: 1996,
pagine: 371 - 374
SICI:
0025-7753(1996)107:10<371:POPMOT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
SPA
Soggetto:
ISLET-CELL ANTIBODIES; GLUTAMIC-ACID DECARBOXYLASE; INSULIN AUTOANTIBODIES; 1ST-DEGREE RELATIVES; HIGH-RISK; IDDM; SECRETION; PERIOD; ONSET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
C. Rodriguezvillar et al., "PRESENCE OF PREDICTIVE MARKERS OF TYPE-I PREDIABETES MELLITUS IN FIRST DEGREE RELATIVES OF TYPE-I DIABETES-MELLITUS", Medicina Clinica, 107(10), 1996, pp. 371-374

Abstract

BACKGROUND: The aim of this study was to analyze the predictive factors of IDDM in firts degree relatives of IDDM patients. SUBJECTS AND METHODS: From 1992 to 1994, 1,053 first degree relatives were screened for measuring islet cell antibodies (ICA) by indirect immunofluorescence (iFl). In all ICA positive subjects, beta cell function was analyzedby intravenous glucose tolerance test (IVGTT) and other immunologic parameters were also studied: anti-insulin antibodies (IAA) by radiobinding and antibodies to glutamic acid decarboxylase (GADAb) by ELISA methods. RESULTS: ICA were found in 3.1% of the first degree relatives. IVGTT showed a significant decrease in acute first phase of insulin response to glucose (IRI 1 minute + 3 minute) in those with ICA greater than or equal to 20 JDF units. In patients with ICA greater than or equal to 20 JDF units, 20% were found to be positive for IAA and 40% were positive for GAdAb. Thirty-one percent (10/32) of ICA positive firstdegree relatives fulfilled prediabetes criteria. During follow-up, 40% (4/10) of these prediabetic patients developed IDDM. CONCLUSION: This study confirms the possibility of identifying among first degree relatives of IDDM patients the subgroup with high risk of developing IDDMthus allowing the initiation of therapy for preventing or delaying IDDM onset.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 14:02:23