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Titolo:
HEMOSTATIC FACTORS AND RISK OF CORONARY-A RTERY DISEASE - FIBRINOGEN,TISSUE-PLASMINOGEN ACTIVATOR AND PLASMINOGEN-ACTIVATOR INHIBITOR-1
Autore:
KIRSCHSTEIN W; SCHERHAG A; STAEDT U; DEMPFLE CE; KELLER H;
Indirizzi:
UNIV HEIDELBERG,KLINIKUM MANNHEIM,MED KLIN 1,FAK KLIN MED MANNHEIM,THEODOR KUTZER UFER D-68135 MANNHEIM GERMANY
Titolo Testata:
Die medizinische Welt
fascicolo: 9, volume: 47, anno: 1996,
pagine: 385 - 393
SICI:
0025-8512(1996)47:9<385:HFAROC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
GER
Soggetto:
ISCHEMIC-HEART-DISEASE; HUMAN ATHEROSCLEROTIC PLAQUES; MYOCARDIAL-INFARCTION; ANGINA-PECTORIS; PLASMA-FIBRINOGEN; FIBRINOLYTIC-ACTIVITY; HEMOSTATIC FUNCTION; ENDOTHELIAL-CELLS; UNSTABLE ANGINA; FACTOR-VII;
Keywords:
CORONARY ARTERY DISEASE; FIBRINOGEN; TISSUE PLASMINOGEN ACTIVATOR; PLASMINOGEN-ACTIVATOR INHIBITOR 1; C-REACTIVE PROTEIN; INHIBITION OF FIBRINOLYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
W. Kirschstein et al., "HEMOSTATIC FACTORS AND RISK OF CORONARY-A RTERY DISEASE - FIBRINOGEN,TISSUE-PLASMINOGEN ACTIVATOR AND PLASMINOGEN-ACTIVATOR INHIBITOR-1", Die medizinische Welt, 47(9), 1996, pp. 385-393

Abstract

The development of IHD in five phases is described, Fibrinogen is a major, independent cardiovascular risk factor. This is documented in six prospective studies. Furthermore fibrinogen is of significant influence in the progression of IHD. tPA-Ag, a marker of PAI 1 activity in plasma, is a new risk indicator for the development and progression of IHD. This is shown by data of the Physicians' Health study and the ECAT-AP study. Experimental and clinical data suggest a role of PAI 1 in the pathogenesis of IHD, yet PAI 1 is not useful as risk indicator forthe progression of the disease. CRP is possibly a marker of disease activity in IHD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 04:50:09