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Titolo:
THE LATENT INHIBITION MODEL OF SCHIZOPHRENIA - FURTHER VALIDATION USING THE ATYPICAL NEUROLEPTIC, CLOZAPINE
Autore:
WEINER I; SHADACH E; TARRASCH R; KIDRON R; FELDON J;
Indirizzi:
TEL AVIV UNIV,DEPT PSYCHOL IL-69978 TEL AVIV ISRAEL
Titolo Testata:
Biological psychiatry
fascicolo: 9, volume: 40, anno: 1996,
pagine: 834 - 843
SICI:
0006-3223(1996)40:9<834:TLIMOS>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIPSYCHOTIC-DRUGS; ATTENTION DISORDER; NEGATIVE SYMPTOMS; CHRONIC AMPHETAMINE; RECEPTOR OCCUPANCY; REAL-TIME; RATS; HALOPERIDOL; ABOLITION; ACQUISITION;
Keywords:
LATENT INHIBITION; CLOZAPINE; SCHIZOPHRENIA; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
I. Weiner et al., "THE LATENT INHIBITION MODEL OF SCHIZOPHRENIA - FURTHER VALIDATION USING THE ATYPICAL NEUROLEPTIC, CLOZAPINE", Biological psychiatry, 40(9), 1996, pp. 834-843

Abstract

Latent inhibition (LI) refers to retarded conditioning to a stimulus that has been repeatedly presented without reinforcement. LI is impaired in schizophrenic patients and in rats treated with amphetamine. Neuroleptic drugs produce two effects in this test paradigm: antagonism of amphetamine-induced disruption of LI, and enhancement of LI when administered on their own. The present experiments tested the effects of the atypical neuroleptic, clozapine, on LI. The experiments used a conditioned emotional response procedure in rats licking for water, consisting of three stages: preexposure, in which the to-be-conditioned stimulus (tone) was repeatedly presented without reinforcement; conditioning, in which the preexposed stimulus was paired with reinforcement (foot shock); and test, in which LI was indexed by animals' degree of suppression of licking during tone presentation. In experiments 1 and 2,the effects of 5.0 and 10.0 mg/kg clozapine on LI were assessed following 20 or 10 tone preexposures, respectively. Experiments 3 and 4 used 40 preexposures and investigated antagonism of amphetamine-induced disruption of LI by 5.0 and 10.0 mg/kg clozapine, respectively. The results demonstrated that clozapine possesses a neuroleptic profile in the LI model, namely, it facilitates the development of LI and antagonizes amphetamine-induced disruption of LI. (C) 1996 Society of Biological Psychiatry.

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Documento generato il 31/03/20 alle ore 20:41:56