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Titolo:
IMMUNODEFICIENCY AND CHRONIC MYELOGENOUS LEUKEMIA-LIKE SYNDROME IN MICE WITH A TARGETED MUTATION OF THE ICSBP GENE
Autore:
HOLTSCHKE T; LOHLER J; KANNO Y; FEHR T; GIESE N; ROSENBAUER F; LOU J; KNOBELOCH KP; GABRIELE L; WARING JF; BACHMANN MF; ZINKERNAGEL RM; MORSE HC; OZATO K; HORAK I;
Indirizzi:
UNIV WURZBURG,INST VIROL & IMMUNBIOL,VERSBACHER STR 7 D-8700 WURZBURGGERMANY UNIV WURZBURG,INST VIROL & IMMUNBIOL D-8700 WURZBURG GERMANY UNIV HAMBURG,HEINRICH PETTE INST HAMBURG GERMANY NICHHD,NATL INST HLTH,LAB MOL GROWTH REGULAT BETHESDA MD 20205 UNIV ZURICH,INST EXPT IMMUNOL CH-8091 ZURICH SWITZERLAND NIAID,NATL INST HLTH,IMMUNOPATHOL LAB BETHESDA MD 20205 RES INST MOL PHARM,DEPT MOL GENET D-12207 BERLIN GERMANY
Titolo Testata:
Cell
fascicolo: 2, volume: 87, anno: 1996,
pagine: 307 - 317
SICI:
0092-8674(1996)87:2<307:IACMLS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON REGULATORY FACTOR; SEQUENCE-BINDING-PROTEIN; FACTOR FAMILY; T-CELLS; HEMATOPOIETIC-CELLS; FACTOR-II; GAMMA; ALPHA; IFN; TRANSCRIPTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
T. Holtschke et al., "IMMUNODEFICIENCY AND CHRONIC MYELOGENOUS LEUKEMIA-LIKE SYNDROME IN MICE WITH A TARGETED MUTATION OF THE ICSBP GENE", Cell, 87(2), 1996, pp. 307-317

Abstract

Interferon consensus sequence binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Mice with a null mutation of ICSBP exhibit two prominent phenotypes related to previously described activities of the IRF family. The fi rst isenhanced susceptibility to virus infections associated with impaired production of IFN gamma. The second is deregulated hematopoiesis in both ICSBP-/- and ICSBP+/- mice that manifests as a syndrome similar to human chronic myelogenous leukemia. The chronic period of the disease progresses to a fatal beast crisis characterized by a clonal expansionof undifferentiated cells. Normal mice injected with cells from mice in blast crisis developed acute leukemia within 6 weeks of transfer. These results suggest a novel role for ICSBP in regulating the proliferation and differentiation of hematopoietic progenitor cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 14:36:54