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Titolo:
INHIBITION OF P42 AND P44 MITOGEN-ACTIVATED PROTEIN-KINASE ACTIVITY BY PD48059 DOES NOT SUPPRESS NERVE GROWTH FACTOR-INDUCED SURVIVAL OF SYMPATHETIC NEURONS
Autore:
VIRDEE K; TOLKOVSKY AM;
Indirizzi:
UNIV CAMBRIDGE,DEPT BIOCHEM,TENNIS COURT RD CAMBRIDGE CB2 1QW ENGLAND UNIV CAMBRIDGE,DEPT BIOCHEM CAMBRIDGE CB2 1QW ENGLAND
Titolo Testata:
Journal of neurochemistry
fascicolo: 5, volume: 67, anno: 1996,
pagine: 1801 - 1805
SICI:
0022-3042(1996)67:5<1801:IOPAPM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAP KINASE; PC12 CELLS; DIFFERENTIATION; CASCADE;
Keywords:
CELL DEATH; APOPTOSIS; P21 RAS; CILIARY NEUROTROPHIC FACTOR; LEUKEMIA INHIBITORY FACTOR; CYCLIC AMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
K. Virdee e A.M. Tolkovsky, "INHIBITION OF P42 AND P44 MITOGEN-ACTIVATED PROTEIN-KINASE ACTIVITY BY PD48059 DOES NOT SUPPRESS NERVE GROWTH FACTOR-INDUCED SURVIVAL OF SYMPATHETIC NEURONS", Journal of neurochemistry, 67(5), 1996, pp. 1801-1805

Abstract

Nerve growth factor (NGF) induces persistent p42 and p44 mitogen-activated protein kinase (MAPK) activity in sympathetic neurones in parallel to its survival-promoting activity. To investigate whether these MAPK activities are necessary for NGF-induced survival, we have inhibited NGF-stimulated p42/p44 MAPK activity over extended periods using thecompound 2-(2'-amino-3'-methoxyphenyl)-oxanaphthalen-4-one (PD98059). Despite attaining up to 95% inhibition of p42/p44 MAPK activity in cultures treated with NGF and PD98059, neuronal survival is maintained undiminished, although a decrease in the density of the neuritic network is observed. Because p21Ras activity is essential for NGF-induced survival, we conclude that p21Ras-linked activities other than p42 and p44 MAPKs are responsible for mediating NGF-dependent survival of rat sympathetic neurones.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:40:05