Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CIRCADIAN VARIATION IN O-6-METHYLGUANINE-DNA METHYLTRANSFERASE ACTIVITY IN MOUSE-LIVER
Autore:
MARTINEAUPIVOTEAU N; CUSSACBUCHDAHL C; CHOLLET P; ROLHION C; DEBITON E; RAPP M; KWIATKOWSKI F; MADELMONT JC; LEVI F;
Indirizzi:
HOP JOUR,CTR JEAN PERRIN,BP 392 F-63011 CLERMONT FERRAN 1 FRANCE UNIV PARIS 11,LAB RYTHMES BIOL & CHRONOTHERAPEUT,ICIG,HOP PAUL BROUSSE F-94800 VILLEJUIF FRANCE INSERM U71 F-63011 CLERMONT FERRAN 1 FRANCE
Titolo Testata:
Anti-cancer drugs
fascicolo: 6, volume: 7, anno: 1996,
pagine: 703 - 709
SICI:
0959-4973(1996)7:6<703:CVIOMA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
O6-METHYLGUANINE-DNA METHYLTRANSFERASE; O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE; POSSIBLE RELEVANCE; ADAPTIVE RESPONSE; ALKYLATING-AGENTS; DNA; REPAIR; CELLS; CHEMOTHERAPY; EXPRESSION;
Keywords:
CHLOROETHYLNITROSOUREAS; CIRCADIAN; LIVER; MICE; O-6-METHYLGUANINE-DNA METHYLTRANSFERASE; RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
N. Martineaupivoteau et al., "CIRCADIAN VARIATION IN O-6-METHYLGUANINE-DNA METHYLTRANSFERASE ACTIVITY IN MOUSE-LIVER", Anti-cancer drugs, 7(6), 1996, pp. 703-709

Abstract

Bifunctional chloroethylating cytostatic agents produce lethal DNA lesions, as a result of the formation of O-6-alkylguanines. These lesions can be repaired by O-6-methylguanine-DNA methyltransferase (MGMT), This ubiquitous nuclear and cytosolic enzyme removes the alkyl group byaccepting it to the cysteine residue of its active site, thus preventing the formation of DNA interstrand cross-links, The role of the circadian organization in cellular protection against such DNA insults wasexamined in male B6D2F1 mice, synchronized with an alternation of 12 h of light and 12 h of darkness (LD12:12). MGMT activity was determined in liver of mice obtained at eight different circadian times, located 3 h apart, MGMT activity varied B-fold along the 24 h time-scale, from 7 +/- 1 pmol/g of tissue at 7 h after light onset (HALO), during the rest span, up to 32 +/- 9 pmol/g at 19 HALO (second mid to late activity span). This large amplitude circadian rhythm in MGMT activity maybe an important determinant of the susceptibility rhythms to alkylating agents, The greatest DNA repair activity occured at night when micewere active, eat and drink, and thus are at a higher risk of being exposed to chemical insults.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:06:40