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Titolo:
RELATIONSHIP BETWEEN MECHANICAL DYSFUNCTION AND DEPRESSION OF SARCOLEMMAL CA2-PUMP ACTIVITY IN HEARTS PERFUSED WITH OXYGEN-FREE RADICALS()
Autore:
MATSUBARA T; DHALLA NS;
Indirizzi:
ST BONIFACE GEN HOSP,RES CTR,DIV CARDIOVASC SCI,351 TACHE AVE WINNIPEG MB R2H 2A6 CANADA ST BONIFACE GEN HOSP,RES CTR,DIV CARDIOVASC SCI WINNIPEG MB R2H 2A6 CANADA UNIV MANITOBA,FAC MED,DEPT PHYSIOL WINNIPEG MB R2H 2A6 CANADA
Titolo Testata:
Molecular and cellular biochemistry
, volume: 161, anno: 1996,
pagine: 179 - 185
SICI:
0300-8177(1996)161:<179:RBMDAD>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL REPERFUSION INJURY; SUPEROXIDE-DISMUTASE; NA+-CA-2+ EXCHANGE; CALCIUM-TRANSPORT; REOXYGENATION; REDUCTION; CATALASE;
Keywords:
OXYGEN FREE RADICALS; CARDIAC CONTRACTILE FAILURE; SARCOLEMMAL CA2+-PUMP ACTIVITY; SARCOLEMMAL CA2+-STIMULATED ATPASE; RAT HEART;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
T. Matsubara e N.S. Dhalla, "RELATIONSHIP BETWEEN MECHANICAL DYSFUNCTION AND DEPRESSION OF SARCOLEMMAL CA2-PUMP ACTIVITY IN HEARTS PERFUSED WITH OXYGEN-FREE RADICALS()", Molecular and cellular biochemistry, 161, 1996, pp. 179-185

Abstract

Although in vitro studies have shown that oxygen free radicals depress the sarcolemmal Ca2+-pump activity and thereby may cause the occurrence of intracellular Ca2+ overload for the genesis of contractile failure, the exact relationship between changes in sarcolemmal Ca2+-pump activity and cardiac function due to these radicals is not clear. In this study we examined the effects of oxygen radicals on sarcolemmal Ca2 uptake and Ca2+-stimulated ATPase activities as well as contractile force development by employing isolated rat heart preparations, When hearts were perfused with medium containing xanthine plus xanthine oxidase, the sarcolemmal Ca2+-stimulated ATPase activity and ATP-dependentCa2+ accumulation were depressed within 1 min whereas the developed contractile force, rate of contraction and rate of relaxation were increased at 1 min and decreased over 3-20 min of perfusion. The resting tension started increasing at 2 min of perfusion with xanthine plus xanthine oxidase, Catalase showed protective effects against these alterations in heart function and sarcolemmal Ca2+-pump activities upon perfusion with xanthine plus xanthine oxidase whereas superoxide dismutasedid not exert such effects. The combination of catalase and superoxide dismutase did not produce greater effects in comparison to catalase alone. These results are consistent with the view that the depression of heart sarcolemmal Ca2+ pump activities may result in myocardial dysfunction due to the formation of hydrogen peroxide and/or hydroxyl radicals upon perfusing the hearts with xanthine plus xanthine oxidase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 23:59:27