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Titolo:
POSTSYNAPTIC INDUCTION OF MOSSY FIBER LONG-TERM DEPRESSION IN DEVELOPING RAT HIPPOCAMPUS
Autore:
GYORI J; ATZORI M; CHERUBINI E;
Indirizzi:
SCH ADV INT STUDIES,BIOPHYS SECTOR,VIA BEIRUT 2-4 I-34014 TRIESTE ITALY SCH ADV INT STUDIES,BIOPHYS SECTOR I-34014 TRIESTE ITALY
Titolo Testata:
NeuroReport
fascicolo: 10, volume: 7, anno: 1996,
pagine: 1660 - 1664
SICI:
0959-4965(1996)7:10<1660:PIOMFL>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNAPTIC PLASTICITY; PYRAMIDAL CELLS; POTENTIATION; NEURONS; LTP; RESOLUTION; EPSCS;
Keywords:
LTD; DEVELOPMENT; HIPPOCAMPUS; CA3 REGION; BAPTA; EXCITATORY POSTSYNAPTIC CURRENTS; FAILURES; PATCH CLAMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
J. Gyori et al., "POSTSYNAPTIC INDUCTION OF MOSSY FIBER LONG-TERM DEPRESSION IN DEVELOPING RAT HIPPOCAMPUS", NeuroReport, 7(10), 1996, pp. 1660-1664

Abstract

THE whole cell configuration of the patch clamp technique was used tostudy the mechanisms of induction of long term depression (LTD) occurring at the messy fibre-CA3 synapse between postnatal (P) da) 6 and P13. In control conditions, when two pulses were delivered to the mossy fibres with an interval of 50 ms a potentiation of the EPSC evoked by the second pulse associated with a reduction in the number of failureswas observed. Tetanization of the moss,: fibres induced LTD of the responses to the first and second stimulus without affecting the paired pulse facilitation. Loading the postsynaptic cell with BAPTA preventedthe induction of LTD but did not modify the paired pulse facilitation, suggesting that LTD induction occurs at the postsynaptic site.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 06:41:31