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Titolo:
MICROVASCULAR ANASTOMOTIC THROMBOSIS IN EXPERIMENTAL DIABETES-MELLITUS
Autore:
COLEN LB; STEVENSON A; SIDOROV V; POTPARIC Z; PACELLI E; SEARLES J; LEE SJ; LI LD;
Indirizzi:
880 KEMPSVILLE RD,SUITE 2600 NORFOLK VA 23502 EASTERN VIRGINIA MED SCH,DEPT PLAST & RECONSTRUCT SURG,MICROSURG RES CTR NORFOLK VA 00000
Titolo Testata:
Plastic and reconstructive surgery
fascicolo: 1, volume: 99, anno: 1997,
pagine: 156 - 162
SICI:
0032-1052(1997)99:1<156:MATIED>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-FUNCTION; BLOOD-FLOW; PENTOXIFYLLINE; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
L.B. Colen et al., "MICROVASCULAR ANASTOMOTIC THROMBOSIS IN EXPERIMENTAL DIABETES-MELLITUS", Plastic and reconstructive surgery, 99(1), 1997, pp. 156-162

Abstract

An experimental model was developed to investigate the effects of glycemic control and pentoxifylline administration on microvascular anastomotic patency rates in streptozotocin-induced diabetic rats. Diabeteswas confirmed by blood glucose levels of more than 300 mg/dl prior toadministering insulin and/or pentoxifylline. Microvascular anastomoses of the femoral artery and vein were performed 4 weeks after induction of diabetes. Subsequently the comparative rates of anastomotic thrombosis in diabetic and nondiabetic groups with or without insulin or pentoxifylline administration were assessed by direct visualization of the anastomotic sites after 4 days. The results suggest that hyperglycemia impairs the postoperative patency of microvascular venous anastomoses. The diabetic animals maintained under insulin regimens that tightly controlled their serum glucose levels (100 to 200 mg/dl) experienced patency rates similar to those of nondiabetic controls (p < 0.05). Pentoxifylline improved microvenous patency at all levels of hyperglycemia studied, suggesting a possible hemorrheologic mechanism for microvascular venous anastomotic thrombus formation in diabetic animals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 11:10:25