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Titolo:
CIRCADIAN-RHYTHM IN TOXIC EFFECTS OF CYSTEMUSTINE IN MICE - RELEVANCEFOR CHRONOMODULATED DELIVERY
Autore:
MARTINEAUPIVOTEAU N; LEVI F; ROLHION C; KWIATKOWSKI F; LEMAIGRE G; FILIPSKI E; CHOLLET P;
Indirizzi:
HOP JOUR,CTR JEAN PERRIN,BP 392 F-63011 CLERMONT FERRAN FRANCE UNIV PARIS 11,ICIG,HOP PAUL BROUSSE,LAB RYTHMES BIOL & CHRONOTHERAPEUT F-94800 VILLEJUIF FRANCE CTR JEAN PERRIN F-63011 CLERMONT FERRAN FRANCE INSERM U71 F-63011 CLERMONT FERRAN FRANCE HOP ANTOINE BECLERE,SERV ANAT PATHOL F-92141 CLAMART FRANCE
Titolo Testata:
International journal of cancer
fascicolo: 5, volume: 68, anno: 1996,
pagine: 669 - 674
SICI:
0020-7136(1996)68:5<669:CITEOC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENCE; CYSTEAMINE; TOLERANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
N. Martineaupivoteau et al., "CIRCADIAN-RHYTHM IN TOXIC EFFECTS OF CYSTEMUSTINE IN MICE - RELEVANCEFOR CHRONOMODULATED DELIVERY", International journal of cancer, 68(5), 1996, pp. 669-674

Abstract

Cystemustine is a new nitrosourea with high anti-tumor activity and ashort plasma half-life in mice. The influence of circadian dosing time upon its toxicities was first investigated in a total of 368 synchronized male B6D2F1 mice. Late survival rate varied from 4% in mice receiving a single dose of cystemustine (conventional lethal dose 50%) at 7 hours after light onset (HALO) up to 88% in mice treated at 15 or at19 HALO. Target organ toxicities (bone marrow, circulating blood cells, spleen, colon and duodenum) were studied following a single slightly lower dose of cystemustine. Leukopenia was the major hematologic effect encountered. Leukocyte count nadir occurred 7 days after injectionand was lowest following cystemustine at 7 HALO as compared to 13 or 19 HALO. Recovery was faster after cystemustine at 19 HALO as comparedto other dosing times. Bone-marrow necrotic lesions were more pronounced I day after cystemustine at 7 HALO than after cystemustine at 19 HALO. Thus, a large-amplitude circadian rhythm characterized the toxicity of this nitrosourea in mice. The lowest cystemustine toxicity was found near the middle of the active span of the rest-activity circadiancycle of mice. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:44:13