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Titolo:
EFFECTS OF SODIUM-AZIDE ON MOTOR-ACTIVITY, MOTOR COORDINATION, AND LEARNING
Autore:
LALONDE R; JOYAL CC; BEAUDIN S;
Indirizzi:
HOP HOTEL DIEU,NEUROL SERV MONTREAL PQ H2W 1T8 CANADA UNIV MONTREAL,HOP HOTEL DIEU,DEPT PSYCHOL MONTREAL PQ H2W 1T8 CANADA NEUROSCI RES CTR MONTREAL PQ H2W 1T8 CANADA
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 56, anno: 1997,
pagine: 67 - 71
SICI:
0091-3057(1997)56:1<67:EOSOMM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LURCHER MUTANT MICE; C OXIDASE DEFICIENCY; ALZHEIMERS-DISEASE;
Keywords:
AZIDE; MOTOR ACTIVITY; SPATIAL LEARNING; MOTOR COORDINATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
R. Lalonde et al., "EFFECTS OF SODIUM-AZIDE ON MOTOR-ACTIVITY, MOTOR COORDINATION, AND LEARNING", Pharmacology, biochemistry and behavior, 56(1), 1997, pp. 67-71

Abstract

Because of the proposed importance of cytochrome oxidase in some neurological disorders, an inhibitor of this enzyme was evaluated in a battery of tests measuring exploration, motor coordination, and learning. Mice injected with sodium azide (6 or 12 mg/kg) were slower to initiate a response in a T maze and had less rears in a small chamber than mice injected with placebo. Drugged mice did not alternate spontaneously even at a minimal retention interval (0 min), but were not impaired in water maze spatial and visual discrimination learning tasks. No group differences emerged in terms of horizontal motor activity and its habituation, number of grooming episodes, and motor coordination. Theseresults indicate that azide-induced slowing of motor activity is situation-specific and is accompanied by abnormalities in choice behavior in a T maze. Copyright (C) 1997 Elsevier Science Inc.

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Documento generato il 01/12/20 alle ore 08:01:49