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Titolo:
TRANSCRIPTS OF INTEGRATED ONCOGENES OF SIMIAN ADENOVIRUS SA7 IN TRANSFORMED SH2 RAT FIBROBLASTS
Autore:
KURABEKOVA RM; BOROVKOVA TV; MISYURINA OY; SATS NV; TAGIEV AF; ZBOROVSKII SS; GRINEVA NI;
Indirizzi:
RUSSIAN ACAD MED SCI,HEMATOL RES CTR MOSCOW 125167 RUSSIA
Titolo Testata:
Molecular biology
fascicolo: 4, volume: 30, anno: 1996,
parte:, 1
pagine: 474 - 480
SICI:
0026-8933(1996)30:4<474:TOIOOS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
E1A PROTEINS; P53; REPRESSION; REGIONS; GENE; RNAS; ACID;
Keywords:
ADENOVIRUS SA7 ONCOGENES; ONCOGENE TRANSCRIPTS; ALTERNATIVE SPLICING; TRANSFORMED RAT CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Kurabekova et al., "TRANSCRIPTS OF INTEGRATED ONCOGENES OF SIMIAN ADENOVIRUS SA7 IN TRANSFORMED SH2 RAT FIBROBLASTS", Molecular biology, 30(4), 1996, pp. 474-480

Abstract

The cell phenotype and transcription of integrated oncogenes of simian adenovirus SA7 were examined In transformed rat fibroblasts SH2(C6). Blot hybridization of cell RNA with oncogene DNA, revealed four transcripts of E1b and about six transcripts of E1a. Using PCR on E1a cDNA with specific primers, followed by electrophoretic separation and sequencing of PCR products, our E1a mRNAs and. their alternative splicing sites were identified. Three main mRNAs arise by removal of 121, 240, and 590 nt. All identified transcripts have a common 3' splicing site (position 1077) and 5' sites at nt 1057, 838: and 588. One of the transcripts was assigned to E1a pre-mRNA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:56:47