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Titolo:
PROTECTIVE ACTION OF HYDROXYETHYL RUTOSIDES ON SINGLET OXYGEN CHALLENGED CARDIOMYOCYTES
Autore:
OLBRICH HG; GRABISCH P; GROSSMANN A; RINNE T; KLEPZIG H; MUTSCHLER E;
Indirizzi:
UNIV FRANKFURT,KARDIOL ABT,MED KLIN 4,THEODOR STERN KAI 7 D-60596 FRANKFURT GERMANY UNIV FRANKFURT,ZENTRUM INNEREN MED D-6000 FRANKFURT GERMANY UNIV FRANKFURT,PHARMAKOL INST NATURWISSENSCH D-6000 FRANKFURT GERMANY
Titolo Testata:
British Journal of Pharmacology
fascicolo: 4, volume: 119, anno: 1996,
pagine: 671 - 676
SICI:
0007-1188(1996)119:4<671:PAOHRO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; CARDIAC MYOCYTES; SUPEROXIDE-DISMUTASE; FROG MESENTERY; RAT; FLAVONOIDS; HEART; PERMEABILITY; QUERCETIN; INHIBITION;
Keywords:
CARDIAC MYOCYTES; REACTIVE OXYGEN SPECIES; RUTOSIDES; THIOBARBITURIC ACID REACTIVE SUBSTANCES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
H.G. Olbrich et al., "PROTECTIVE ACTION OF HYDROXYETHYL RUTOSIDES ON SINGLET OXYGEN CHALLENGED CARDIOMYOCYTES", British Journal of Pharmacology, 119(4), 1996, pp. 671-676

Abstract

1 The effect of a standardized mixture of beta-hydroxyethyl rutosidesagainst oxidative damage in singlet oxygen-challenged isolated cardiac myocytes from adult rats was investigated. The morphology of the myocytes was evaluated as an indicator for cell viability (elongated, rodshaped cells vs. hypercontracted, rounded cells). The determination of the production of thiobarbituric acid reactive substances served as an indicator for lipid peroxidation. 2 Exposure to singlet oxygen which was generated by photo-excitation of rose bengal (10(-7) M) reduced the number of rod shaped (vital) cardiomyocytes by 78.5 +/- 2.5% and increased the production of thiobarbituric acid reactive substances by 1180 +/- 150% in comparison to incubation with control buffer. 3 Coincubation of the cells with beta-hydroxyethyl rutosides (concentration range: 6.7 pg ml(-1) to 670 mu g ml(-1)) increased the number of rod shaped cardiomyocytes after exposure to singlet oxygen in a dose-dependent bell-shaped manner. A significant protective effect was observed atbeta-hydroxyethyl rutosides concentrations ranging from 0.67 ng ml(-1) to 67 ng ml(-1). 4 In spite of their protective action, beta-hydroxyethyl rutosides did not reduce the accumulation of thiobarbituric acidreactive substances, used as an indicator for lipid peroxidation. 5 The data suggest that beta-hydroxyethyl rutosides exert a protective action against oxygen radical-induced damage of cardiac myocytes at verylow concentrations without interfering with lipid peroxidation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:54:40