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Titolo:
IMPAIRED ARTERIAL REACTIVITY FOLLOWING CYTOMEGALOVIRUS-INFECTION IN THE IMMUNOSUPPRESSED RAT
Autore:
EERDMANS PHA; PERSOONS MCJ; DEBETS SJM; BOUDIER HAJS; SMITS JFM; BRUGGEMAN CA; DEMEY JGR;
Indirizzi:
UNIV LIMBURG,DEPT PHARMACOL,POB 616 NL-6200 MD MAASTRICHT NETHERLANDS UNIV LIMBURG,DEPT PHARMACOL NL-6200 MD MAASTRICHT NETHERLANDS UNIV LIMBURG,CARDIOVASC RES INST MAASTRICHT,DEPT MED MICROBIOL NL-6200 MD MAASTRICHT NETHERLANDS
Titolo Testata:
British Journal of Pharmacology
fascicolo: 4, volume: 119, anno: 1996,
pagine: 637 - 646
SICI:
0007-1188(1996)119:4<637:IARFCI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; SMOOTH-MUSCLE CELLS; RESISTANCE ARTERIES; SEPTIC SHOCK; L-ARGININE; VIRUS; ATHEROSCLEROSIS; ATHEROGENESIS; HYPOTENSION; ENDOTOXIN;
Keywords:
CYTOMEGALOVIRUS; RESISTANCE ARTERIES; SYMPATHETIC NERVOUS SYSTEM; ADRENERGIC RESPONSES; ENDOTOXIN; LPS; NO SYNTHASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
P.H.A. Eerdmans et al., "IMPAIRED ARTERIAL REACTIVITY FOLLOWING CYTOMEGALOVIRUS-INFECTION IN THE IMMUNOSUPPRESSED RAT", British Journal of Pharmacology, 119(4), 1996, pp. 637-646

Abstract

1 Cytomegalovirus (CMV) is a major pathogen in immunocompromised individuals and may participate in the pathogenesis of atherosclerosis in the general population. We evaluated whether CMV-infection alters the function of arterial smooth muscle. 2 Blood pressure (BP) and arterialreactivity were recorded in immunosuppressed rats that had been infected with CMV (10(5) plaque forming units i.p.). Furthermore, the reactivity of isolated arteries was compared between CMV-infected rats and rats injected with bacterial endotoxin (LPS). 3 Initially resting BP and heart rate (HR) were not modified in CMV-infected rats, but baroreflex control of HR was impaired. By the eighth day post-CMV, BP droppedprecipitously and could no longer be raised by phenylephrine (PHE). 4In mesenteric resistance arteries, isolated at this stage from CMV-infected rats, contractile responses to nerve stimulation, noradrenaline, PHE and 5-hydroxytryptamine (5-HT) were virtually absent while thoseto high potassium and vasopressin (AVP) were not modified. In aortae of CMV-infected rats, responses to 5-HT and AVP were impaired while those to PHE or potassium were hardly affected. Reduced contractile responses could not be restored by N-G-nitro-L-arginine methyl ester (L-NAME). 5 Continuous treatment of CMV-infected rats with prazosin (0.1 mgkg(-1) day(-1)) prevented blood pressure lowering and resistance artery changes. 6 Observations in arteries of LPS-treated rats (5-10 mg kg(-1), i.p.) differed markedly from those in vessels of Ch?V-infected animals. The contractile reactivity of their mesenteric resistance arteries was not altered while in their aortae, responses to PHE, 5-HT andAVP were reduced. With the exception of the AVP responses, this was more pronounced in the presence of L-arginine and reversed by L-NAME. 7These findings indicate that CMV-infection results in a reduction of resistance artery reactivity and hypotonia. This seems not to involve cytokine-mediated induction of NO synthase in the vascular wall but may be due to alterations of excitation-contraction coupling in arterialsmooth muscle in response to increased sympathetic nervous input.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 09:22:57