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Titolo:
KINETICS OF INTERLEUKIN-6 PRODUCTION AFTER EXPERIMENTAL-INFECTION OF MICE WITH SCHISTOSOMA-MANSONI
Autore:
KHALIL RMA; HULTNER L; MAILHAMMER R; LUZ A; MOELLER J; MOHAMED AA; OMRAN S; DORMER P;
Indirizzi:
GSF MUNICH,INST EXPT HAMATOL,MARCHIONINISTR 25 D-81377 MUNICH GERMANY GSF MUNICH,INST EXPT HAMATOL D-81377 MUNICH GERMANY GSF MUNICH,INST PATHOL MUNICH GERMANY CAIRO UNIV,DEPT CLIN PATHOL CAIRO EGYPT THEODOR BILHARZ RES INST CAIRO EGYPT
Titolo Testata:
Immunology
fascicolo: 2, volume: 89, anno: 1996,
pagine: 256 - 261
SICI:
0019-2805(1996)89:2<256:KOIPAE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; GROWTH-ENHANCING ACTIVITY; GRANULOMA-FORMATION; TH2 CYTOKINES; ACID; CELLS; RNA; PURIFICATION; EXPRESSION; MODULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
R.M.A. Khalil et al., "KINETICS OF INTERLEUKIN-6 PRODUCTION AFTER EXPERIMENTAL-INFECTION OF MICE WITH SCHISTOSOMA-MANSONI", Immunology, 89(2), 1996, pp. 256-261

Abstract

It has been reported that interleukn-6 (IL-6) is expressed in cells of acute inflammatory granulomas experimentally induced in mice by eggsof Schistosoma mansoni. Moreover, in vitro IL-6 was shown to enhance the cytotoxic activity of human platelets against larvae of S. mansoni. To elucidate further a proposed biological significance of this cytokine during the course of schistosomiasis, we studied tile kinetics ofIL-6 production and concomitantly performed a histopathological analysis of the livers in BALB/c mice subcutaneously infected with S. mansoni cercariae. Over a period of 24 weeks postinfection (p.i.) we monitored serum IL-6 levels. IL-6 production in vitro by pokeweed mitogen (PWM)-stimulated spleen cells as well as IL-6 mRNA expression in livers,spleens and kidneys. We found significantly elevated IL-6 levels in (PWM)-stimulated spleen cell-conditioned media (SCM) at weeks 6 to 20 p.i., peaking at week 10 p.i. In contrast, serum IL-6 concentrations started lu rise not before week 8 but remained significantly elevated above normal control values until week 24 p.i. The time pattern of enhanced IL-6 mRNA expression detected in spleens and livers, but nut ill kidneys, as well as rite rises of IL-6 in SCM and with a delay of 2 weeks in serum samples correlated with the onset of the egg-induced inflammatory reactions as well as the incidence and tile number of the granulomas observed histopathologically in the livers of infected mice. Our data emphasize both a local and a. systemic role of IL-6 in the hostimmune response Following infection of mice with S. mansoni.

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Documento generato il 27/10/20 alle ore 04:18:23