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Titolo:
MATERNAL DEXAMETHASONE TREATMENT ENHANCES THE EXPRESSION OF SURFACTANT APOPROTEIN-A IN THE HYPOPLASTIC LUNG OF RABBIT FETUSES INDUCED BY OLIGOHYDRAMNIOS
Autore:
ASABE K; HASHIMOTO S; SUITA S; SUEISHI K;
Indirizzi:
KYUSHU UNIV 60,FAC MED,DEPT PATHOL 1,HIGASHI KU,3-1-1 MAIDASHI FUKUOKA 81212 JAPAN KYUSHU UNIV,FAC MED,DEPT PEDIAT SURG FUKUOKA 812 JAPAN KYUSHU UNIV,FAC MED,DEPT PATHOL 1 FUKUOKA 812 JAPAN
Titolo Testata:
Journal of pediatric surgery
fascicolo: 10, volume: 31, anno: 1996,
pagine: 1369 - 1375
SICI:
0022-3468(1996)31:10<1369:MDTETE>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
FETAL-RAT LUNG; PULMONARY SURFACTANT; PRETERM RABBITS; ACCELERATED APPEARANCE; POSTNATAL STIMULATION; SP-A; CORTICOSTEROIDS; BETAMETHASONE; INDUCTION; MATURATION;
Keywords:
PULMONARY HYPOPLASIA; OLIGOHYDRAMNIOS; MATERNAL DEXAMETHASONE TREATMENT; SURFACTANT APOPROTEIN A; IMMUNOHISTOCHEMISTRY; IMAGE ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
K. Asabe et al., "MATERNAL DEXAMETHASONE TREATMENT ENHANCES THE EXPRESSION OF SURFACTANT APOPROTEIN-A IN THE HYPOPLASTIC LUNG OF RABBIT FETUSES INDUCED BY OLIGOHYDRAMNIOS", Journal of pediatric surgery, 31(10), 1996, pp. 1369-1375

Abstract

Previously the authors reported that oligohydramnios induced lung hypoplasia in rabbit fetuses and showed that sustained oligohydramnios, which was induced by amniotic shunting from gestational sacs into the maternal peritoneal cavity between 23 and 30 days' gestation, significantly retards not only lung structural growth but also the functional development of alveolar type II cells in surfactant apoprotein A (SP-A)expression. In the present study, the authors examined, both immunohistochemically and morphometrically, whether the maternal administration of dexamethasone restored SP-A synthesis in fetal hypoplastic lungs. The fetal rabbits were treated through maternal administration of dexamethasone (0.25 mg/kg/d) or saline 48 and 24 hours before delivery, at 30 days' gestation. The ratio of lung weight to body weight was significantly greater for the dexamethasone-treated fetuses compared with the saline-treated fetuses in both the shunted and the nonshunted groups (P < .05). Compared with the lungs of the saline-treated fetuses, those of the dexamethasone-treated fetuses had a statistically significant increase in SP-A expression, namely the number of SP-A-positive type II cells per unit area (P < .001), the ratio of SP-A-positive cellsto the total number of cells (P < .01), and the percentage of SP-A-positive area per unit area (P < .05) in the shunted group. An increase in the ratio of SP-A-positive area to lung interstitial was found for the shunted group. However, similar findings were not observed in the nonshunted group. The results suggest that maternal dexamethasone treatment accelerates the functional development of alveolar type II cellsin SP-A expression, even in hypoplastic lungs induced by oligohydramnios. Copyright (C) 1996 by W.B. Saunders Company

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:53:02