Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CONTRIBUTION OF MITOCHONDRIAL PROTON LEAK TO SKELETAL-MUSCLE RESPIRATION AND TO STANDARD METABOLIC-RATE
Autore:
ROLFE DFS; BRAND MD;
Indirizzi:
UNIV CAMBRIDGE,DEPT BIOCHEM,TENNIS COURT RD CAMBRIDGE CB2 1QW ENGLAND
Titolo Testata:
American journal of physiology. Cell physiology
fascicolo: 4, volume: 40, anno: 1996,
pagine: 1380 - 1389
SICI:
0363-6143(1996)40:4<1380:COMPLT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDATIVE-PHOSPHORYLATION; INNER MEMBRANE; GLUCOSE-UPTAKE; ATP TURNOVER; HEPATOCYTES; HINDQUARTER; EXERCISE;
Keywords:
THERMOGENESIS; COUPLING EFFICIENCY; RAT; P/O RATIO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
D.F.S. Rolfe e M.D. Brand, "CONTRIBUTION OF MITOCHONDRIAL PROTON LEAK TO SKELETAL-MUSCLE RESPIRATION AND TO STANDARD METABOLIC-RATE", American journal of physiology. Cell physiology, 40(4), 1996, pp. 1380-1389

Abstract

We have tested the hypothesis that the leak of protons across the mitochondrial inner membrane (proton leak) is a significant contributor to standard metabolic rate (SMR). We found that proton leak accounts for around one-half of the resting respiration rate of perfused rat skeletal muscle. Proton leak is known to make a significant (26%) contribution to the resting respiration rate of isolated rat hepatocytes (M. D. Brand, L.-F. Chien, E. K. Ainscow, D. F. S. Rolfe, and R. K. Porter. Biochim. Biophys. Acta 1187: 132-139, 1994). If the importance of proton leak in these isolated and perfused systems is similar to its importance in vivo, then using literature values for the contribution of liver and skeletal muscle to SMR, we can calculate that proton leak in liver and skeletal muscle alone accounts for 11-26% (mean 20%) of the SMR of the rat. If proton leak activity in the other tissues of the rat is similar to that in liver cells, then the contribution of proton leak to rat SMR would be 16-31% (mean 25%).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 17:28:14