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Titolo:
TALL-CELL VARIANT OF PAPILLARY THYROID-CANCER - DISREGARDED ENTITY
Autore:
RUTER A; NISHIYAMA R; LENNQUIST S;
Indirizzi:
LINKOPING UNIV HOSP,DEPT ENDOCRINOL & METAB SURG & MED S-58185 LINKOPING SWEDEN MAINE MED CTR,DEPT PATHOL PORTLAND ME 04102
Titolo Testata:
World journal of surgery
fascicolo: 1, volume: 21, anno: 1997,
pagine: 15 - 21
SICI:
0364-2313(1997)21:1<15:TVOPT->2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGNOSTIC SCORING SYSTEM; DNA CONTENT; RETROSPECTIVE ANALYSIS; FOLLOW-UP; CARCINOMA; CLASSIFICATION; THYROGLOBULIN; THERAPY; DISEASE; GLAND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
A. Ruter et al., "TALL-CELL VARIANT OF PAPILLARY THYROID-CANCER - DISREGARDED ENTITY", World journal of surgery, 21(1), 1997, pp. 15-21

Abstract

The tall-cell variant of papillary thyroid carcinoma (TCV) has been described as an aggressive tumor with a significantly higher incidence of recurrence and mortality than other forms of papillary carcinoma. In some series it has accounted for up to 10%, whereas in other series it has not been reported at all, indicating that there are difficulties identifying it, In a series of 162 consecutively treated patients with papillary thyroid carcinoma treated by total thyroidectomy according to a highly standardized procedure, all specimens were specifically examined by an international group of pathologists to establish the occurrence of TCV, All patients with TCV were studied with regard to local aggressiveness, the presence of metastases, iodine uptake, DNA pattern, thyroglobulin production, treatment (surgical and adjuvant), and outcome (follow-up 3-17 years, median 10 years), At primary histopathologic evaluation by the local pathologist, three patients were recorded as having TCV, At special evaluation by the expert group, eight morecases were found, giving a total of 11 patients in this series (7%), Five of them had extracapsular growth, and four were multifocal, Threehad metastases at the time of admission. Seven tumors were diploid, one tetraploid, and three aneuploid, Of the three patients with primarydistant metastases two died (8 and 24 months after operation), and one is still alive after 10 years, Four other patients developed recurrences, one of whom died from cardiac failure, but the others have so far been treated successfully, Two of these recurrences had no radioiodine uptake, and one had no rise in thyroglobulin concentrations; the other two had rising values that correlated with recurrence, The other four patients are alive without recurrence. It,vas concluded that identification of the TCV requires examination by an experienced pathologist. Moreover, it may have a higher incidence than is generally recognized, No reliable criteria for prognostic classification were identified, The results suggest that early identification and active treatment can lead to an outcome more favorable than has previously been described.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 17:47:53