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Titolo:
ATRIAL-NATRIURETIC-PEPTIDE IN MULTIPLE SYSTEM ATROPHY
Autore:
BEVILACQUA M; NORBIATO G; RIGHINI V; CASTELLI L; ROGOLINO A; FURLAN R; PIAZZA S; CHEBAT E; VAGO T;
Indirizzi:
OSPED L SACCO,SERV ENDOCRINOL,DIV MED 2,VIA GB GRASSI 74 I-20157 MILAN ITALY
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 4, volume: 40, anno: 1996,
pagine: 1047 - 1053
SICI:
0363-6119(1996)40:4<1047:AIMSA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOPRESSIN RELEASE; ENDOCRINE RESPONSES; AUTONOMIC FAILURE; VOLUME EXPANSION; NERVOUS-SYSTEM; ANF RELEASE; HUMANS; SECRETION; HYPOTENSION; HYPOXIA;
Keywords:
VASOPRESSIN; SINOAORTIC RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M. Bevilacqua et al., "ATRIAL-NATRIURETIC-PEPTIDE IN MULTIPLE SYSTEM ATROPHY", American journal of physiology. Regulatory, integrative and comparative physiology, 40(4), 1996, pp. 1047-1053

Abstract

Central nervous system feedback loops centered on hypothalamic neurons control atrial natriuretic peptide (ANP). We evaluated the ANP response to arterial hypotension, isotonic blood volume expansion, and increase in plasma osmolality in 14 patients with multiple system atrophy (MSA). Seven of the patients were characterized by a lack of vasopressin response to hypotension (MSA type B), suggesting chronic sinoaorticdenervation, and seven by a preserved response (MSA type A). Orthostatic hypotension decreased ANP in controls and type A patients, whereasANP in type B was not affected. Isotonic saline infusion increased ANP and diuresis in controls and type A patients, whereas it did not affect ANP in type B. Osmotic load increased plasma osmolality and vasopressin in controls and MSA patients and ANP in controls and type A but not in type B patients. In MSA patients with altered afferent control of vasopressin, ANP secretion is not stimulated by blood volume expansion, osmotic load, or blood pressure, suggesting that afferent excitatory control plays a role in the release of ANP.

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Documento generato il 12/07/20 alle ore 02:55:06