Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SUSCEPTIBILITY TO NATURAL-KILLER-CELLS AND DOWN-REGULATION OF MHC CLASS-I EXPRESSION IN ADENOVIRUS-12 TRANSFORMED-CELLS ARE REGULATED BY DIFFERENT E1A DOMAINS
Autore:
HUVENT I; COUSIN C; KISS A; BERNARD C; DHALLUIN JC;
Indirizzi:
INST RECH SCI CANC,INSERM,U124,1 PL VERDUN F-59045 LILLE FRANCE INST RECH SCI CANC,INSERM,U124 F-59045 LILLE FRANCE
Titolo Testata:
Virus research
fascicolo: 2, volume: 45, anno: 1996,
pagine: 123 - 134
SICI:
0168-1702(1996)45:2<123:STNADO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGHLY ONCOGENIC ADENOVIRUS-12; TOXIC LYMPHOCYTES-T; RAT-CELLS; TRANSCRIPTION ACTIVATION; CELLULAR-TRANSFORMATION; GENE-EXPRESSION; RODENT CELLS; REGION E1A; NK CELLS; PROTEIN;
Keywords:
ADENOVIRUS; E1A; E1B; MHC-CLASS I; NATURAL KILLER CELLS; SEROTYPES; TRANSFORMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
I. Huvent et al., "SUSCEPTIBILITY TO NATURAL-KILLER-CELLS AND DOWN-REGULATION OF MHC CLASS-I EXPRESSION IN ADENOVIRUS-12 TRANSFORMED-CELLS ARE REGULATED BY DIFFERENT E1A DOMAINS", Virus research, 45(2), 1996, pp. 123-134

Abstract

All human adenoviruses transform rodent cells in vitro, but only cells transformed by serotypes belonging to subgroups A (Ad12) and B (Ad3)are tumorigenic for immunocompetent animals. In these cells, the expression of MHC-class I antigens is repressed and might allow them to escape from recognition by cytotoxic T lymphocytes (CTL) and to develop in tumor. Furthermore, these cell lines appear resistant to lysis by natural killer (NK) cells. To determine the E1A domain(s) responsible for these properties several cell lines were created by transforming baby rat kidney (BRK) cells with a set of plasmids expressing different Ad2/Ad12 hybrid E1A gene products. The MHC class I gene expression wasinhibited in cells expressing the Ad12 13S mRNA product and in cells transformed with Ad2/Ad12 hybrid E1A gene product harboring the C-terminal part of the conserved region (CR) 3 of Ad12. Susceptibility of these transformed cell lines to NK cells was determined by cytolytic assays. The results obtained suggest that two Ad12 E1A domains are required to induce resistance of the cell lines to NK cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:01:11