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Titolo:
GROWTH OF HUMAN HERPESVIRUS-6 IN HEPG2 CELLS
Autore:
CERMELLI C; CONCARI M; CARUBBI F; FABIO G; SABBATINI AMT; PECORARI M; PIETROSEMOLI P; MEACCI M; GUICCIARDI E; CARULLI N; PORTOLANI M;
Indirizzi:
UNIV MODENA,DEPT BIOMED SCI,VIA CAMPI 287 I-41100 MODENA ITALY UNIV MODENA,DEPT BIOMED SCI I-41100 MODENA ITALY UNIV HOSP,DEPT INTERNAL MED I-41100 MODENA ITALY UNIV HOSP,CTR DIAG VIRAL DIS I-41100 MODENA ITALY
Titolo Testata:
Virus research
fascicolo: 2, volume: 45, anno: 1996,
pagine: 75 - 85
SICI:
0168-1702(1996)45:2<75:GOHHIH>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXANTHEM-SUBITUM; T-CELLS; INFECTION; VIRUS; HEPATITIS; HHV-6; INVITRO; INFANT; IDENTIFICATION; REPLICATION;
Keywords:
HEPG2; HUMAN HERPESVIRUS 6 (HHV-6); HUMAN HERPESVIRUS 7 (HHV-7); LATENCY; PHORBOL; REACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
C. Cermelli et al., "GROWTH OF HUMAN HERPESVIRUS-6 IN HEPG2 CELLS", Virus research, 45(2), 1996, pp. 75-85

Abstract

HepG2 cells, a well differentiated liver cell line, were shown to be permissive for both human herpesvirus 6 (HHV-6) A and B strains by three independent methods of analysis: detection of viral antigens, viralDNA sequences and infectious virus. HepG2 cell infection with HHV-6 resulted in functional damage as shown by the increased release in the culture medium of some hepatocyte markers. Cells surviving the acute infection were serially passaged without showing cytopathic effect, but, some months later, HHV-6 DNA was still present in the cells and virus induction with a phorbol ester was successful. A possible pathogenetic role of HHV-6 in liver diseases is discussed. Experiments of HepG2 infection with human herpesvirus 7 (HHV-7) were also carried out. The lack of an efficient virus replication suggested a difficulty for HHV-7 to infect hepatic cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 03:33:02