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Titolo:
LOCALIZATION OF THE SITE OF THE IGG MOLECULE THAT REGULATES MATERNOFETAL TRANSMISSION IN MICE
Autore:
MEDESAN C; RADU C; KIM JK; GHETIE V; WARD ES;
Indirizzi:
UNIV TEXAS,SW MED CTR,DEPT MICROBIOL DALLAS TX 75235 UNIV TEXAS,SW MED CTR,DEPT MICROBIOL DALLAS TX 75235 UNIV TEXAS,SW MED CTR,CTR CANC IMMUNOBIOL DALLAS TX 75235 ROMANIAN ACAD,CTR IMMUNOL BUCHAREST ROMANIA
Titolo Testata:
European Journal of Immunology
fascicolo: 10, volume: 26, anno: 1996,
pagine: 2533 - 2536
SICI:
0014-2980(1996)26:10<2533:LOTSOT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
FC-RECEPTOR; IMMUNOGLOBULIN-G; NEONATAL MICE; COMPLEX; FETAL; RAT; FRAGMENT; BINDING; PROTEIN;
Keywords:
IGG; MATERNOFETAL TRANSMISSION; NEONATAL FC RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
C. Medesan et al., "LOCALIZATION OF THE SITE OF THE IGG MOLECULE THAT REGULATES MATERNOFETAL TRANSMISSION IN MICE", European Journal of Immunology, 26(10), 1996, pp. 2533-2536

Abstract

Site-directed mutagenesis of a recombinant Fc hinge fragment has recently been used to localize the site of the mouse IgG1 (mIgG1) moleculethat is involved in the intestinal transfer of recombinant Fc hinge fragments in neonatal mice. This site encompasses Ile-253, His-310, Gln-311, His-433 and Asn-434, localized at the CH2-CH3 domain interface and overlapping with the staphylococcal protein A-binding and catabolicsites. In the present study, the effect of these mutations on the maternofetal transfer of Fc hinge fragments has been studied. Experimentsto analyze transfer of radiolabeled Fc hinge fragments from the circulation of 15-18 day pregnant mice to fetuses in utero demonstrate thatthe mutations affect the maternofetal transmission in a way that correlates closely with the effects of the mutations on intestinal transfer and catabolism. The studies indicate that the neonatal Fc receptor, FcRn, is involved in transcytosis across both yolk sac and neonatal intestine in addition to the regulation of IgG catabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:55:01