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Titolo:
ENHANCED PRODUCTION OF IL4 BUT NOT OF IFN-GAMMA AND IL10 BY PERIPHERAL-BLOOD MONONUCLEAR-CELLS FROM ATOPIC CHILDREN IN RESPONSE TO CD2 PLUSCD28 STIMULATION
Autore:
HOLTER W; EMMINGER W; MAJDIC O; KNAPP W;
Indirizzi:
ST ANNA CHILDRENS HOSP,CCRI,KINDERSPITALGASSE 6 A-1090 VIENNA AUSTRIA UNIV VIENNA,VIRCC,INST IMMUNOL VIENNA AUSTRIA ALLERGIEAMBULATORIUM RENNWEG VIENNA AUSTRIA
Titolo Testata:
Pediatric allergy and immunology
fascicolo: 2, volume: 7, anno: 1996,
pagine: 75 - 82
SICI:
0905-6157(1996)7:2<75:EPOIBN>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-CD2 MONOCLONAL-ANTIBODIES; HUMAN T-CELLS; HUMAN-LYMPHOCYTES; B-CELLS; INTERLEUKIN-4; IL-4; IGE; ACTIVATION; DIFFERENTIATION; ASSOCIATION;
Keywords:
CHILDREN; ATOPY; CYTOKINES; IL4; CD2 STIMULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
W. Holter et al., "ENHANCED PRODUCTION OF IL4 BUT NOT OF IFN-GAMMA AND IL10 BY PERIPHERAL-BLOOD MONONUCLEAR-CELLS FROM ATOPIC CHILDREN IN RESPONSE TO CD2 PLUSCD28 STIMULATION", Pediatric allergy and immunology, 7(2), 1996, pp. 75-82

Abstract

Peripheral blood mononuclear cells from 16 children with atopic disease (range of IgE levels: 33 - 2892 kU/l) and 12 age matched controls were stimulated either with mAbs specific for CD3, CD2, CD3 plus CD28, CD2 plus CD28, with Tetanus Toroid, SEA, or PHA plus PMA and their cell proliferation was determined. In addition, their cytokine production(IL2, IL4, IL10, IFN gamma) following selected stimuli was measured. We found that the cells from atopics proliferated significantly betterin response to CD2 stimulation than control cells, with no differencein response to CD3 or SEA stimulation. Furthermore, cells from atopics produced significantly higher amounts of IL4 than cells from controls, a difference most pronounced following CD2 plus CD28 stimulation. No differential production was found for IL10 and IFN gamma. We conclude that in atopic children with moderately elevated IgE a hyperreactivity of the CD2 pathway of stimulation and a clear elevation of IL4 but not of IL10 or IFN gamma production can be demonstrated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:40:56