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Titolo:
EXPRESSION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 MESSENGER-RNA AND PROTEIN IN CULTURED HUMAN THYROCYTES
Autore:
KASAI K; BANBA N; MOTOHASHI S; HATTORI Y; MANAKA K; SHIMODA SI;
Indirizzi:
DOKKYO UNIV,SCH MED,DEPT ENDOCRINOL INTERNAL MED MIBU TOCHIGI 32102 JAPAN DOKKYO UNIV,SCH MED,CTR TISSUE CULTURE MIBU TOCHIGI 32102 JAPAN
Titolo Testata:
FEBS letters
fascicolo: 2, volume: 394, anno: 1996,
pagine: 137 - 140
SICI:
0014-5793(1996)394:2<137:EOMCPM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD MONONUCLEAR LEUKOCYTES; TUMOR-NECROSIS-FACTOR; MESSENGER-RNA; CHEMOTACTIC PROTEIN-1; GENE-EXPRESSION; CC-CHEMOKINES; CYTOKINE; INTERLEUKIN-1; INDUCTION; MCP-1;
Keywords:
THYROCYTE; MONOCYTE CHEMOATTRACTANT PROTEIN-1; INTERLEUKIN-1; TUMOR NECROSIS FACTOR-ALPHA; INTERFERON-GAMMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
K. Kasai et al., "EXPRESSION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 MESSENGER-RNA AND PROTEIN IN CULTURED HUMAN THYROCYTES", FEBS letters, 394(2), 1996, pp. 137-140

Abstract

Monocytes as well as lymphocytes infiltrate in the stroma of thyroid tissue in autoimmune and destructive thyroiditis, Monocyte chemoattractant protein-1 (MCP-1) is a cytokine that attracts T-lymphocytes as well as monocytes, Using human thyrocytes in primary cultures, we show that expression of MCP-1 mRNA and protein is remarkably stimulated by both interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha), and also that interferon-gamma (IFN-gamma) by itself is a weak stimulant but has a synergistic activity with either IL-1 or TNF-alpha. The finding indicates that MCP-1 can be produced by thyrocytes themselves, suggesting a possible role of thyrocytes on accumulation of monocytes and T-lymphocytes to the tissue from the blood in autoimmune and destructive thyroiditis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 14:49:20