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Titolo:
THE MOUSE POLY (C)-BINDING PROTEIN EXISTS IN MULTIPLE ISOFORMS AND INTERACTS WITH SEVERAL RNA-BINDING PROTEINS
Autore:
FUNKE B; ZULEGER B; BENAVENTE R; SCHUSTER T; GOLLER M; STEVENIN J; HORAK I;
Indirizzi:
FORSCH INST MOL PHARMAKOL,KRAHMERSTR 6 D-12207 BERLIN GERMANY FORSCH INST MOL PHARMAKOL D-12207 BERLIN GERMANY UNIV WURZBURG,INST IMMUNOL & VIROL WURZBURG GERMANY THEODOR BOVERI INST BIOWISSENSCH,LEHRSTUHL ZELL & ENTWICKLUNGSBIOL WURZBURG GERMANY UNIV WURZBURG,INST MED STRAHLENKUNDE & ZELLFORSCH WURZBURG GERMANY CNRS,INST GENET & BIOL MOL & CELLULAIRE STRASBOURG FRANCE
Titolo Testata:
Nucleic acids research
fascicolo: 19, volume: 24, anno: 1996,
pagine: 3821 - 3828
SICI:
0305-1048(1996)24:19<3821:TMP(PE>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
KH DOMAIN; MOLECULAR-CLONING; MESSENGER-RNA; HNRNP-K; C-MYC; GENE; CELL; ASSOCIATION; EXPRESSION; SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
B. Funke et al., "THE MOUSE POLY (C)-BINDING PROTEIN EXISTS IN MULTIPLE ISOFORMS AND INTERACTS WITH SEVERAL RNA-BINDING PROTEINS", Nucleic acids research, 24(19), 1996, pp. 3821-3828

Abstract

The murine poly(C)-binding protein (mCBP) was previously shown to belong to the group of K-homology(KH) proteins by virtue of its homology to hnRNP-K. We have isolated cDNA-splice variants of mCBP which differby two variable regions of 93 bp and/or 39 +/- 3 bp respectively. Both variable regions are located between the second and third KH-domain of mCBP. The characterization of a partial genomic clone enabled us topropose a model for the generation of the second variable region by the use of a putative alternative spl ice signal. The mCBP mRNA is expressed ubiquitously and the protein is found predominantly in the nucleus with the exception of the nucleoli. We have identified five proteins which interact with mCBP in the yeast two hybrid system: mouse y-boxprotein 1 (msy-1), y-box-binding protein, hnRNP-L, filamin and splicing factor 9G8. The interaction between mCBP and splicing factor 9G8 was confirmed in vivo. These results suggest a function of mCBP in RNA metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:52:07