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Titolo:
POSSIBLE ROLE OF THE V3 DOMAIN OF GP120 IN RESISTANCE TO AN AMPHOTERICIN-B DERIVATIVE (MS8209) BLOCKING HUMAN-IMMUNODEFICIENCY-VIRUS ENTRY
Autore:
PLESKOFF O; SOL N; MARRAKCHI H; SERLIN M; SEMAN M; ALIZON M;
Indirizzi:
INST COCHIN GENET MOL,INSERM,U332,22 RUE MECHAIN F-75014 PARIS FRANCE INST COCHIN GENET MOL,INSERM,U332 F-75014 PARIS FRANCE UNIV PARIS 07,LAB IMMUNODIFFERENCIAT F-75005 PARIS FRANCE
Titolo Testata:
Journal of virology
fascicolo: 11, volume: 70, anno: 1996,
pagine: 8247 - 8251
SICI:
0022-538X(1996)70:11<8247:PROTVD>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD4 BINDING; ENVELOPE GLYCOPROTEIN; MONOCLONAL-ANTIBODIES; HIV-1 REPLICATION; CELL-FUSION; TYPE-1; INFECTION; GENE; INHIBITION; SEQUENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
O. Pleskoff et al., "POSSIBLE ROLE OF THE V3 DOMAIN OF GP120 IN RESISTANCE TO AN AMPHOTERICIN-B DERIVATIVE (MS8209) BLOCKING HUMAN-IMMUNODEFICIENCY-VIRUS ENTRY", Journal of virology, 70(11), 1996, pp. 8247-8251

Abstract

MS8209, an amphotericin B derivative blocking human immunodeficiency virus type 1 (HIV-1) entry after CD4 binding, neutralized the HIV-2 strains EHO and ROD(10) but not ROD(CEM). In the V3 domain of gp120, ROD(CEM) differed from ROD(10) at two positions (a threonine instead of an isoleucine at position 312 and an arginine instead of a glutamine atposition 329), and drug resistance was conferred to HIV-1 by substitution of the ROD(CEM) V3 but not the ROD(10) V3. V3 mutations may prevent the interaction of gp120 with MS8209 or modify the mechanism of virus entry, rendering it less accessible to neutralization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:17:46